Correlation of cell necrosis and tissue calcification with ischemia/reperfusion injury after liver transplantation

Transplantation Proceedings
George N TzimasP P Metrakos

Abstract

The cellular events following liver ischemia/reperfusion (I/R) during transplantation are largely unknown. The spectrum of I/R damage to the liver can be clinically revealed by the development of primary graft dysfunction or nonfunction. Because viral-induced liver necrosis has been associated with the development of calcifications in an animal model, we investigated the spectrum of I/R changes identified at an ultrastructural level among livers after liver transplant (LT). Random liver biopsies from five recipients with different degrees of liver dysfunction (LD) were processed for light (LM) and electron (EM) microscopic examination. The degree of calcification was estimated as mild-moderate or severe. The degree of cell vacuolization, used as a surrogate marker of cell necrosis, was reported as mild-moderate or severe. Two patients with severe LD had obvious calcifications by LM and EM examinations. Both showed significant vacuole formation, suggesting a severe degree of cell necrosis, and both succumbed to the sequelae of their LD. One patient showed evidence of mild calcifications at EM (but not LM) examination, with mild vacuole formation. The remaining two patients displayed no microcalcifications. Both presented only mi...Continue Reading

References

Mar 13, 2002·Transplantation·Ergun VelidedeogluJames F Markmann
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Citations

Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fariba KalantariPatrick Auguste
Apr 2, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Xiao-Bo Chen, Ming-Qing Xu
Oct 10, 2013·Ageing Research Reviews·David Yang-Wei FannThiruma V Arumugam
Mar 28, 2017·Journal of Cellular Physiology·Zahra HoseiniHamed Mirzaei
Nov 13, 2010·Ultrastructural Pathology·Geoffrey A Talmon, James L Wisecarver
Sep 27, 2018·Nature Reviews. Gastroenterology & Hepatology·Robert F Schwabe, Tom Luedde
Jul 6, 2019·Cell Calcium·Julien AnractThierry Capiod
Aug 24, 2021·Clinical Journal of Gastroenterology·Peilin LiSusumu Eguchi

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