Correlation of changes in brain indoleamine metabolism with onset of anorexia in rats

American Journal of Surgery
M F von MeyenfeldtJ E Fischer

Abstract

The association of elevated brain serotonergic activity with cancer anorexia was investigated in three experiments. Significant increases in whole brain tryptophan, serotonin and 5-hydroxyindoleacetic acid in anorectic rats bearing methylcholanthrene sarcomas demonstrated the general nature of this phenomenon. In the Walker 256 sarcoma model, significant increases in whole brain serotonin and 5-hydroxyindoleacetic acid immediately preceded the onset of anorexia, suggesting that these changes in serotonin activity were not caused by decreased food intake. Investigations of regional brain changes in serotonin activity of rats bearing Walker 256 tumors revealed widespread increases in tryptophan, while serotonin was increased in the diencephalon and cerebellum and 5-hydroxyindoleacetic acid was increased in the cortex, hippocampus, diencephalon, pons-medulla and cerebellum. Therefore, these experiments demonstrate that increased brain serotonin activity is a general phenomenon, being observed in two lines of anorexia-producing tumors, that it precedes the onset of anorexia and that selective increases in serotonin activity occur within different regions of the brain.

References

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Citations

Sep 1, 1988·Pharmacology, Biochemistry, and Behavior·W T ChanceJ E Fischer
Feb 10, 1990·Lancet
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·W T ChanceJ E Fischer
Feb 1, 1988·Regulatory Peptides·G L WillisG C Smith
Jan 1, 1984·Peptides·F M van LammerenJ E Fischer
Nov 5, 1998·Regulatory Peptides·W T ChanceA Balasubramaniam
Feb 1, 1996·Hematology/oncology Clinics of North America·M Shike
Jul 1, 1996·Nutrition·W T Chance, J E Fischer
Jul 1, 1988·Annals of Surgery·K C Fearon, D C Carter
Jan 1, 1983·American Journal of Surgery·H I KarlbergJ E Fischer
Jan 27, 2006·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Eric Van Cutsem, Jann Arends
Nov 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·M M MeguidF Rossi-Fanelli
Jun 1, 1983·The British Journal of Surgery·R I WesdorpM F von Meyenfeldt
Jan 1, 1995·Surgical and Radiologic Anatomy : SRA·F A SaadehF A Haikal
Sep 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S J WimalawansaH K Datta
Jan 1, 1992·Surgical and Radiologic Anatomy : SRA·S JaegersH J de Jongh
Jan 1, 1992·Surgical and Radiologic Anatomy : SRA·S KirollesA R el-Bakaury
Jul 1, 1984·Hospital Practice·J C Meeroff
Jan 1, 1987·Annals of the New York Academy of Sciences·R A Hoerr, V R Young
Dec 3, 1984·Klinische Wochenschrift·G OllenschlägerJ Schindler
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·J A FinkelsteinJ E Fischer
Nov 1, 1983·The American Journal of Medicine·R S RivlinP Sherlock
May 1, 1984·The Journal of Surgical Research·W T ChanceJ E Fischer

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