Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid

The Knee
Nobuyuki KumahashiYuji Uchio

Abstract

We sought to determine whether a clinical association exists between osteoarthritis (OA)-associated knee pain and adenosine triphosphate (ATP) levels in synovial fluid (SF). A total of 28 patients with 28 primary OA knees were included. They routinely received intra-articular injection of high-molecular-weight hyaluronic acid (HA) once weekly for 5 weeks (treated group). Eight patients without knee pain who had undergone an operation for anterior or posterior cruciate ligament reconstruction 2 years ago were also examined (control group). SF and blood ATP concentrations, total amount of ATP, total SF volume, and Visual Analogue Scale (VAS) scores in all patients were measured and we compared pre-treatment values with those 1 week after the final treatment. We evaluated the correlation of change in total ATP (ΔATP) and change in VAS score (ΔVAS), ΔVAS and change in SF volume (ΔSF), and ATP concentration in SF and blood. In the treated group, SF ATP concentration, total amount of ATP, SF volume, and VAS score were all significantly lower post-treatment than pre-treatment (p = 0.0005, 0.0003, 0.0022, and < 0.0001, respectively). In treated group, ΔVAS was significantly associated with ΔATP (r = 0.56, p = 0.0032), ΔSF was significa...Continue Reading

References

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Citations

Aug 15, 2013·Purinergic Signalling·Geoffrey BurnstockIsabel R Orriss
Apr 18, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ayman F HegabMustafa G Khallaf
Jun 2, 2014·Current Opinion in Pharmacology·Ning Wang, Alison Gartland
Jul 20, 2016·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·Bryan T TorresSteven C Budsberg
Nov 14, 2018·Clinical and Experimental Immunology·M H J van den Bosch
Oct 21, 2016·Nature Reviews. Rheumatology·Meriam NeflaClaire Jacques
Dec 9, 2017·Cartilage·Roy D AltmanJun Takeuchi
Feb 11, 2020·Frontiers in Pharmacology·Carmen Corciulo, Bruce N Cronstein
Dec 21, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Juliana Maia TeixeiraCláudia Herrera Tambeli
May 2, 2018·Frontiers in Veterinary Science·Olga KrupkovaAntonio Pozzi
Apr 26, 2019·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Amy BronstoneVinod Dasa
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Jun 23, 2020·Journal of Nutrition and Metabolism·Elena V TchetinaEugeniya P Sharapova
Oct 4, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jeffrey L Krajewski

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