PMID: 517279Jan 1, 1979Paper

Correlation of changes in the GABA-ergic system with the development of spasticity in paraplegic cats

Advances in Experimental Medicine and Biology
N E NaftchiW D Horst

Abstract

Following spinal cord transection there occurred decreases in Km and Vmax of glutamate decarboxylase (GAD) both above and below the lesion, and an initial decrease in the concentration of GABA. Concomitantly, there was a gradual decrease in presynaptic inhibition. Eight to 12 weeks after spinal cord transection, Km and Vmax for GAD returned to control values, but the GABA content of the spinal cord below the lesion increased significantly and presynaptic inhibition became maximally depressed. These results suggested that during the chronic phase of spinal cord injury there is a decrease in release of GABA, the interneuronal inhibitory neurotransmitter which mediates presynaptic inhibition. Diazepam, a GABA enhancer, increased presynaptic inhibition in acute and chronic spinal cats, this being accompanied by a reduction in somatic muscular spasticity. The degree of this enhancement by diazepam, however, is attenuated with gradual loss of presynaptic inhibition. In the acute cat, a conditioning volley applied to cutaneous afferents blocked the inhibition of the monosynaptic response to extensor motoneurones. In contrast, in chronic spinal cats (eight to 12 weeks), the duration of complete blockade was markedly reduced and was fol...Continue Reading

Citations

Sep 28, 2004·American Journal of Physical Medicine & Rehabilitation·Ross ZafonteElie Elovic
Feb 17, 2005·Muscle & Nerve·Jean-Michel Gracies
Jan 1, 1990·Annals of the New York Academy of Sciences·N E Naftchi
Feb 1, 1985·Annals of Neurology·R A Davidoff
Jan 1, 1985·Medicinal Research Reviews·G Bartholini
Feb 16, 1999·Journal of Neurotrauma·D J BennettJ Cheng

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