PMID: 9161951May 1, 1997Paper

Correlation of clinical characteristics and small bowel histopathology in celiac disease

Journal of Pediatric Gastroenterology and Nutrition
Z WeizmanA Porath

Abstract

Literature information regarding clinical and histological correlates in celiac disease is limited. The present study was designed to assess the value of various clinical parameters in predicting the severity of small bowel histopathology. Small bowel biopsy specimens of 59 children with established celiac disease (ESPGAN criteria) were evaluated blindly. Morphology was evaluated based on a common histopathology score. The following clinical variables were evaluated: age at diagnosis, duration of symptoms, severity score of clinical symptoms, severity score of physical signs, and growth parameters (height and weight Z scores). Multiple regression analysis was performed to evaluate the relative importance of each clinical parameter. Only three clinical variables revealed a significant correlation with the histopathology score. The symptom severity score (t = 3.883, p = 0.0003) demonstrated a positive correlation. The two others, age at diagnosis (t = 3.076, p = 0.0032) and duration of symptoms (t = -2.987, p = 0.0041), revealed a negative correlation. We conclude that more severe clinical symptoms of a shorter duration, presented at a younger age, are better predictors of a more severe form of small bowel histopathology in child...Continue Reading

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Citations

Nov 2, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Dimitrios TapsasKarin Fälth-Magnusson
Jun 13, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hussein Abu DayaPeter H Green
Oct 16, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Juha TaavelaKatri Kaukinen
Sep 20, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P BrarP H R Green
Apr 3, 2014·Journal of Pediatric Gastroenterology and Nutrition·Youssef GhazzawiImad Absah
Mar 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Amy Lowichik, Linda Book
Feb 26, 2020·Journal of Pediatric Gastroenterology and Nutrition·Sofia KrögerLaura Kivelä

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