Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Rewa MalhotraBhawna Mahajan

Abstract

Oral squamous cell carcinoma (OSCC) accounts for 90 % of malignant lesions of oral cavity. The study assessed the potential of Cyfra 21-1 as a tumor marker in OSCC. The study included 50 patients of OSCC to evaluate levels of Cyfra 21-1 in serum and saliva by electrochemiluminescent immunoassay (ECLIA) and CK19 messenger RNA (mRNA) expression in tissue by florescent quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) along with healthy individuals as control. The salivary and serum Cyfra 21-1 levels in patients of OSCC were significantly higher compared to controls (p value < 0.01). There was a 2.75-fold increase in CK19 mRNA expression in OSCC cases compared to controls. A significant positive correlation was found between serum and salivary Cyfra 21-1, serum Cyfra 21-1, and CK19 mRNA expression and between salivary Cyfra 21-1 and CK19 mRNA expression. Among these, correlation between serum and salivary Cyfra 21-1 was highly significant. Salivary and serum Cyfra 21-1 showed significantly elevated levels in grade II OSCC compared to grade I histopathologically. Elevated levels of salivary Cyfra 21-1 were associated with recurrence in OSCC patients. Reverse operating curve constructed using 3 ng/ml as...Continue Reading

References

Jun 1, 1987·Scandinavian Journal of Dental Research·G AnnerothM Luna
Feb 1, 1995·Archives of Otolaryngology--head & Neck Surgery·I DoweckN Gruener
Oct 1, 1995·Clinical Otolaryngology and Allied Sciences·V BongersG B Snow
Mar 17, 2001·International Journal of Cancer. Journal International Du Cancer·K DohmotoJ Takahara
Aug 25, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GadducciA R Genazzani
Apr 23, 2002·Journal of Cellular Biochemistry·Michael A SheardDalibor Valik
Dec 26, 2002·Journal of Surgical Oncology·Hemangini H VoraPriya R Chikhlikar
Apr 17, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Bin ChengRobert J Griffin
Jul 6, 2004·Clinical Biochemistry·Vivian BarakRoland Einarsson
Nov 16, 2005·The Annals of Otology, Rhinology, and Laryngology·Philippe CéruseFrançois Disant
Mar 31, 2006·The Journal of the American Dental Association·David T Wong
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rafael NaglerRaphael Feinmesser
Sep 13, 2006·International Journal of Oral and Maxillofacial Surgery·L-P ZhongZ-Y Zhang
Jul 7, 2007·Archives of Oral Biology·Lai-ping ZhongZhi-yuan Zhang
Jan 22, 2008·Oral Oncology·Sharada S SawantMilind M Vaidya
Sep 23, 2008·Oral Oncology·Saman Warnakulasuriya
Jan 1, 2010·The Open Dentistry Journal·Anastasios K MarkopoulosGeorgios Tzimagiorgis
Jul 23, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Abhigyan SatyamAlpana Sharma
Apr 25, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·M AkhterMotiur R Molla

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Citations

Aug 17, 2018·International Journal of Dental Hygiene·Hatem W AmerDalia H El-Rouby
Feb 7, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·John AdeoyePeter Thomson
Feb 4, 2019·Pathology Oncology Research : POR·K Hema ShreeR Sundar
Jan 29, 2020·Expert Review of Molecular Diagnostics·José M AmenábarChamindie Punyadeera
Jun 16, 2021·Journal of Pharmaceutical and Biomedical Analysis·Shayma ShaikhRakesh Rawal

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