PMID: 15364643Sep 15, 2004Paper

Correlation of cytokine and mobility in mice with arthritis and during therapy with Swertia chirayita

Journal of Herbal Pharmacotherapy
Pradeep KumarAshok K Sexana

Abstract

We attempt to derive a correlation between pro-inflammatory cytokines and mobility in arthritic mice and after treatment with Swertia chirayita plant extract. Tumor necrosis factor-á (TNF-á), interleukin-1alpha (IL-1alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured by solid phase sandwich ELISA and the different parameters of mobility [distance traveled (DT), resting time (RT), ambulatory time (AT) and stereotypic time (ST)] was monitored and recorded by an Auto track system. Joint circumference of the right hind limb was monitored using a Vernier caliper. Our preliminary findings revealed that DT and RT correlated well with IL-1alpha, TNF-alpha and IL-10 levels in the joint homogenates of arthritic mice and after therapy with Swertia chirayita extracts. AT and ST showed poor correlation with the cytokines. Thus we demonstrate here the anti-inflammatory property of Swertia chirayita and its usage in the prevention of arthritis in the broader aspect in the management of associated cytokines.

References

Mar 1, 1997·Clinical and Experimental Immunology·A MüssenerL Klareskog
Feb 12, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M L BlivenI G Otterness
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·S OhshimaT Kishimoto
Mar 22, 2001·The New England Journal of Medicine·E H Choy, G S Panayi

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