Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
N SneigeBanu K Arun

Abstract

Cytologic evaluation of ductal lavage or random periareolar fine-needle aspiration (FNA) specimens has been proposed to improve risk stratification of women at high risk for breast cancer. However, cytologic assessment of morphologic changes is subjective. To assess the utility of fluorescence in situ hybridization (FISH) in the categorization of breast lesions, we prospectively evaluated 32 random periareolar FNA specimens from 27 women at high risk for breast cancer. Cytologic specimens were prepared using the thin preparation technique, and diagnoses were made on the basis of previously published criteria. Specimens were also evaluated by FISH for chromosomes 1, 8, 11, and 17. Monosomy was defined as the loss of one signal or both signals in >20% of cells, and polysomy was defined as the presence of > or = 3 signals in >6% of cells. Cytologic smears from seven invasive ductal carcinomas and nine benign breast specimens from women at low risk for breast cancer were included for comparison. In the high-risk group, cytologic findings were nonproliferative epithelium (NPE) in 16 cases and hyperplasia in 16 cases. Chromosomal aberrations were detected in 11 (69%) of 16 NPE cases, 14 (89%) of 16 hyperplasia cases, seven (100%) of ...Continue Reading

References

Jan 1, 1994·Human Pathology·M A MicaleS R Wolman
Apr 1, 1996·Human Pathology·N SneigeA El-Naggar
May 9, 2000·Journal of the American College of Surgeons·C BottiA M Cianciulli
Nov 8, 2001·Journal of the National Cancer Institute·W C DooleyE B King
Dec 6, 2001·Journal of the National Cancer Institute·M R WrenschM Rhys
Oct 2, 2002·Breast Cancer Research and Treatment·Tanja FehmJonathan Uhr

❮ Previous
Next ❯

Citations

Aug 23, 2011·Journal of Biosciences·Natasa Todorovic-Rakovic
Jan 16, 2007·Current Opinion in Obstetrics & Gynecology·Benjaporn Chaiwun, Paul Thorner
Apr 9, 2011·Genetics and Molecular Research : GMR·R C P C SilvaK K V O Moura
Feb 6, 2016·Genes, Chromosomes & Cancer·Vladimira KoudelakovaMarian Hajduch
Mar 6, 2009·The Lancet Oncology·Monica M ReinholzRobert B Jenkins
Feb 9, 2007·Cancer Letters·Jane Bayani, Jeremy A Squire
Oct 17, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·S Verma, P Dey
Aug 3, 2013·Journal of Clinical Pathology·Maria OrsariaPei Hui
Aug 26, 2016·Breast Cancer : Basic and Clinical Research·David N Danforth
Aug 14, 2019·Scientific Reports·Altuna HalilovicPeter Bult
Dec 27, 2016·Molecular Cytogenetics·Mathew Bloomfield, Peter Duesberg
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Banu ArunNour Sneige

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.