Correlation of Demarcation Line Depth With Medium-Term Efficacy of Different Corneal Collagen Cross-Linking Protocols in Keratoconus

Cornea
Ali MesenSuleyman Okudan

Abstract

To compare demarcation line depth (DD) and topographic changes among different corneal collagen cross-linking (CXL) protocols and to evaluate the relation of DD with medium-term efficacy of CXL in halting progression of keratoconus. The study included 124 patients (mean age 19 ± 4.8 years) with progressive keratoconus who underwent conventional (3 mW/cm/30 min), accelerated (18 mW/cm/5 min), or transepithelial (TE) CXL (3 mW/cm/30 min) and followed up for at least 2 years. Baseline and final corneal topographic parameters and DD determined with anterior segment optical coherence tomography 1 month after CXL were compared among the protocols and the correlation between DD and topographic changes at the end of 24 months was analyzed. P < 0.05 was considered as statistically significant. Mean DD was significantly higher in the conventional and accelerated groups (335.19 ± 71.13 μm and 304.97 ± 94.45 μm, respectively) compared with the TE group (239.92 ± 71.37 μm) (P < 0.001). After conventional and TE CXL, keratometric parameters improved remarkably, whereas accelerated CXL only lowered K1 and Kmax (P < 0.05). No correlation was found between DD and topographic changes (P > 0.05). Progression was detected in 3 eyes in the conventi...Continue Reading

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Citations

Nov 3, 2020·European Journal of Ophthalmology·Sandra HoyekJoelle Antoun
Jan 13, 2021·Journal of Refractive Surgery·Alex MatthysFrançois Malecaze
Feb 23, 2021·Seminars in Ophthalmology·Sidi Mohamed Hamida AbdelkaderDavid P Piñero
Mar 26, 2021·The Cochrane Database of Systematic Reviews·Sueko M NgIrene C Kuo

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