Correlation of different circulating endothelial progenitor cells to stages of diabetic retinopathy: first in vivo data

Investigative Ophthalmology & Visual Science
Simon BrunnerGuntram Schernthaner

Abstract

To investigate vasculogenic circulating progenitor cells (CPCs), endothelial progenitor cells (EPCs), and mature EPCs in patients with type 1 diabetes mellitus (T1DM) with or without diabetic retinopathy (DR). A case-control study comparing 90 patients with T1DM with and without DR was performed. Patients were studied and staged for retinopathy according to the Early Treatment of Diabetic Retinopathy Study (ETDRS) classification. Ninety patients were included: 30 without DR (control [CO]), 30 with mild nonproliferative DR (mNPDR), 10 with moderate-severe NPDR (msNPDR), 10 with mild-moderate proliferative diabetic retinopathy (mmPDR), and 10 with high-risk PDR (hrPDR). CPCs (CD34/CD133), EPCs (CD34/CD133/CD309), and mature EPCs (CD34/CD133/CD309/CD31) were enumerated by flow cytometry. EPCs were reduced in mNPDR (114 +/- 66; P < 0.001) and msNPDR (77 +/- 40; P = 0.042) compared with CO (244 +/- 115). In contrast, EPCs were unchanged in mmPDR (248 +/- 155) compared with CO. Strikingly, EPCs were augmented in hrPDR (389 +/- 124) compared with all other stages. Numbers of undifferentiated progenitor cells (CPCs) did not differ among CO, mmPDR, and hrPDR. Augmentation (3x) of mature EPCs in hrPDR (325 +/- 118; P < 0.001) compared wi...Continue Reading

Citations

May 30, 2013·Blood Cells, Molecules & Diseases·D BarthelmesW Y Shen
May 23, 2012·International Journal of Vascular Medicine·Gopi Krishna KolluruChristopher G Kevil
Jun 11, 2011·Patient Preference and Adherence·Barbara WirostkoAndreas Pleil
Jan 24, 2013·Diabetes Care·Thomas HörtenhuberGerit-Holger Schernthaner
Aug 9, 2011·Experimental Diabetes Research·Stella BernardiPaola Secchiero
Dec 21, 2010·Archivos de la Sociedad Española de Oftalmología·A Villalvilla, R Fernández-Durango
Oct 16, 2012·Seminars in Nephrology·Richard E GilbertDarren A Yuen
Jun 28, 2011·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Liu-mei HuLi Wei-Ye
Mar 2, 2010·Microvascular Research·Sergio Li CalziMaria B Grant
Mar 31, 2016·Current Diabetes Reports·Giuseppe Mangialardi, Paolo Madeddu
Sep 24, 2013·Journal of Diabetes and Its Complications·Thomas J PovsicMiriam C Morey
May 2, 2014·Frontiers in Endocrinology·Noemi LoisAlan W Stitt
Jun 18, 2014·Frontiers in Endocrinology·Grace C DaveyTimothy O'Brien
May 6, 2011·Diabetes Care·Angelo AvogaroGian Paolo Fadini
Jul 5, 2016·Journal of Diabetes Research·Olga Simó-ServatCristina Hernández
Jul 14, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ying WangHua Yan
Mar 20, 2010·Circulation Research·Yagna P R Jarajapu, Maria B Grant
Apr 20, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Kai-Hang Yiu, Hung-Fat Tse
Apr 22, 2009·Acta Diabetologica·Zdenka DjuricJost B Jonas
Sep 13, 2011·Amino Acids·Ross Milne, Seymour Brownstein
Oct 1, 2010·Menopause : the Journal of the North American Menopause Society·Lena SjöbergRisto Kaaja
Feb 23, 2019·Journal of Cardiovascular Translational Research·Chi-Sheng LuHung-I Yeh
May 6, 2015·The Journal of Clinical Endocrinology and Metabolism·Mauro RigatoGian Paolo Fadini
Jan 16, 2015·European Journal of Ophthalmology·Kristina BlaslovLea Duvnjak
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Angelo Avogaro, Gian Paolo Fadini
Oct 15, 2019·Current Eye Research·Pietro Maria BertelliReinhold J Medina
Jul 27, 2018·Journal of Diabetes Research·Bou-Yue PengHong-Jian Wei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.