Correlation of drug-induced apoptosis assay results with oncologist treatment decisions and patient response and survival

Cancer
Linda D BossermanCary A Presant

Abstract

An observational prospective nonblinded clinical trial was performed to determine the effect of a drug-induced apoptosis assay results on treatments planned by oncologists. Purified cancer cells from patient biopsies were placed into the MiCK (Microculture Kinetic) assay, a short-term culture, which determined the effects of single drugs or combinations of drugs on tumor cell apoptosis. An oncologist received the assay results before finalizing the treatment plan. Use of the MiCK assay was evaluated and correlated with patient outcomes. Forty-four patients with successful MiCK assays from breast cancer (n = 16), nonsmall cell lung cancer (n = 6), non-Hodgkin lymphoma (n = 4), and others were evaluated. Four patients received adjuvant chemotherapy after MiCK, and 40 received palliative chemotherapy with a median line of therapy of 2. Oncologists used the MiCK assay to determine chemotherapy (users) in 28 (64%) and did not (nonusers) in 16 patients (36%). In users receiving palliative chemotherapy, complete plus partial response rate was 44%, compared with 6.7% in nonusers (P < .02). The median overall survival was 10.1 months in users versus 4.1 months in nonusers (P = .02). Relapse-free interval was 8.6 months in users versus 4...Continue Reading

References

Aug 4, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deborah SchragUNKNOWN ASCO Working Group on Chemotherapy Sensitivity and Resistance Assays
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James H Doroshow
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Citations

Jul 6, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E C GrendysT J Herzog
Jan 23, 2016·Journal of Translational Medicine·Christophe Bounaix Morand du PuchMuriel Mathonnet
Jan 6, 2021·International Journal of Molecular Sciences·Tanya SinghSanaz Memarzadeh

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