PMID: 9659667Jul 11, 1998Paper

Correlation of electrophysiology, neurochemistry and axonal projections of guinea-pig sphincter of Oddi neurones

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
K Hillsley, G M Mawe

Abstract

Sphincter of Oddi (SO) ganglia are comprised of two main types of neurones based either on their electrical or neurochemical properties. This study investigated whether any correlation exists between the electrical and neurochemical properties of these cells. SO neurones were characterized electrically as either Tonic or Phasic cells, labelled with neurobiotin, fixed, and processed for beta-nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-DA) staining and choline acetyltransferase immuno-reactivity to identify whether electrically characterized neurones were nitrergic or cholinergic. A total of 119 cells were analysed in this manner; 45% of cells were Tonic and 37% were Phasic. An equivalent number of Tonic (58.1%, 18/31) and Phasic cells (60%, 21/35) were choline acetyltransferase (ChAT) positive. Three of 34 Phasic cells were NADPH-DA positive, whereas 11/33 Tonic cells were NADPH-DA positive. In none of the preparations was ChAT immunoreactivity and NADPH-DA reactivity ever observed in the same neurone. Calretinin immunoreactivity was present in a subpopulation of both Tonic and Phasic neurones. No correlation was observed between the direction of axon projections and the electrophysiological or neurochemical pr...Continue Reading

References

Oct 1, 1976·Seminars in Roentgenology·M J Palayew
Feb 1, 1992·The Journal of Physiology·J F Tack, J D Wood
Jan 1, 1988·Regulatory Peptides·C DahlstrandH Ahlman
Mar 22, 1988·European Journal of Pharmacology·P R Wade, J D Wood
Jun 1, 1988·The Journal of Clinical Investigation·J W WileyC Owyang
Apr 1, 1984·The Journal of Surgical Research·E L MullerH A Pitt
Jan 30, 1995·The Journal of Comparative Neurology·D G WellsG M Mawe
Mar 6, 1995·The Journal of Comparative Neurology·M SchemannM Mäder
Jan 1, 1993·American Journal of Surgery·H S KaufmanK D Lillemoe
Jan 1, 1997·Neuroscience·W A KunzeJ C Bornstein
May 12, 1997·Journal of the Autonomic Nervous System·E K TalmageG M Mawe

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Citations

May 12, 1997·Journal of the Autonomic Nervous System·E K TalmageG M Mawe
Feb 24, 2001·Journal of Autonomic Pharmacology·F Vogalis, T K Smith
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C M WoodsG T P Saccone
Aug 31, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A A Izzo
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Onesmo B BalembaGary M Mawe
Jul 17, 1999·The American Journal of Physiology·G M Mawe, A L Kennedy
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B P Manning, G M Mawe

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