Correlation of end-diastolic pressure and myocardial elasticity with the transit time of the left atrial pressure wave (A-Ar interval)

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
E G BrennanM J Walsh

Abstract

Contraction of the left atrium in diastole generates a pressure wave that moves along the postero-lateral wall of the left ventricle (LV), rebounds off the LV apex, and is then directed toward the outflow tract. The movement of this atrial pressure wave may be detected with pulsed Doppler echocardiography by placing a sample volume in the LV outflow tract. The resulting spectral profile shows the initial. A velocity wave and also the Ar velocity wave, which is caused by the atrial pressure wave rebounding off the LV apex. The transit time from the inflow tract to the outflow tract of the atrial pressure wave (A-Ar interval) may be determined from the time axis of the spectral profile by measuring the peak-to-peak separation of the A and Ar, velocity waves. It occurs in the range 25 to 80 milliseconds. The primary determinant of the A-Ar interval is the elasticity of the LV myocardium. We correlated ventricular elasticity with the A-Ar interval in 47 patients and found a significant negative linear correlation (r = -0.782, p < 0.001). Because the pressure in a viscoelastic conduit such as the LV is determined by the elasticity of the ventricular wall, we correlated end-diastolic pressure with the A-Ar interval and again showed a...Continue Reading

References

Feb 1, 1978·Circulation Research·S A Glantz, W W Parmley
Nov 1, 1977·The American Journal of Cardiology·K SagawaK M Bakalar
Aug 1, 1975·The Journal of Clinical Investigation·G H TempletonJ H Mitchell

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Citations

Sep 7, 2014·Basic Research in Cardiology·Cristina PislaruSorin V Pislaru
Mar 31, 2007·The International Journal of Cardiovascular Imaging·Filippos TriposkiadisGlafkos Kelepeshis
Jul 30, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Wen-Chol VoonSheng-Hsiung Sheu

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