Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series

The American Journal of the Medical Sciences
Ajay BansalSandy Hall

Abstract

The epidermal growth factor receptor (EGFR) pathway is important to colorectal carcinogenesis. Although EGFR is described to be overexpressed in adenomas, to the authors' knowledge, its relationship with advanced features in adenomas and as a marker for adenoma progression has not been studied. Initially, 13 polyps (sizes 3 mm-5.5 cm) from a 63-year-old patient were stained for EGFR. Subsequently, a validation group of 95 adenomas from 16 patients were graded semiquantitatively for EGFR staining. Size and villous features of the adenomas were evaluated by 2 independent pathologists and compared with EGFR expression. To be classified as advanced, adenomas needed to be greater than 1 cm and fulfill 1 of the 2 criteria-villous component >20% to 25% or presence of high-grade dysplasia. In the index case, the large 5.5 cm tubulovillous adenoma had EGFR positivity in all of its neoplastic cells, whereas another 2 cm tubular adenoma with focal villous features had 30% EGFR positivity. All other polyps and normal colonic mucosa were negative for EGFR. In 95 adenomas from 16 additional patients, there was a significant correlation of EGFR positivity with adenoma size ≥1 cm and villous features (all P < 0.001). The odds of EGFR expressio...Continue Reading

References

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KoretzP Möller
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Feb 25, 2000·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·I PorebskaT Bojarowski
Dec 21, 2000·Current Oncology Reports·S SundaresanM X Sliwkowski
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Reade B RobertsDavid W Threadgill
May 15, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akishi OoiYoh Dobashi
Oct 6, 2005·Journal of the National Cancer Institute·Brenda K EdwardsLinda W Pickle
Jan 26, 2007·Expert Opinion on Biological Therapy·Nicolas Moosmann, Volker Heinemann
Nov 16, 2007·The New England Journal of Medicine·Derek J JonkerMalcolm J Moore
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Urszula DoughertyMarc Bissonnette

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Citations

Jun 16, 2011·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Sanjay Harrison, Harrison Benziger
Jul 17, 2015·Clinical and Translational Gastroenterology·Juan ZhouThomas D Wang
Jul 1, 2016·Physiological Reviews·Jianchun ChenRaymond C Harris
Oct 13, 2020·Advanced Functional Materials·Stephan RogallaStefan Harmsen
Dec 19, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jolien J TjalmaWouter B Nagengast

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