PMID: 9655222Jul 9, 1998Paper

Correlation of epidermal growth factor receptor and radiosensitivity in human maxillary carcinoma cell lines

Acta Oto-laryngologica
M MiyaguchiT Kubo

Abstract

To determine the relationship between epidermal growth factor receptor (EGFR) and radiosensitivity, we immunostained cells from three maxillary carcinoma cell lines with an anti-EGFR antibody. The intensity of staining reactivity, determined by means of an image analysis system, was expressed as grey value (0-black to 255-white). The mean grey values for cell lines IMC-2, IMC-3, and IMC-4 were 181, 210, and 222, respectively, and differed significantly (p < 0.001). This indicates that IMC-2 had the highest number of EGFR, followed by IMC-3 and IMC-4. The cells were then irradiated at 1, 2, 4, or 6 Gy, and cell survival was assessed by means of a standard colony-forming assay. IMC-2 had the highest survival rates at 1, 2 and 4 Gy, followed by IMC-3 and IMC-4. Therefore, the survival rates for IMC-2, IMC-3, and IMC-4 after irradiation increased in proportion to the amount of EGFR in each cell line. These results support the findings of previous clinical studies which showed that increased expression of EGFR was associated with higher recurrence rates of glottic and maxillary sinus carcinoma in patients treated with radiation therapy. The amount of EGFR in cells may therefore be associated with their radiosensitivity.

References

Jun 1, 1992·The Annals of Otology, Rhinology, and Laryngology·S KomiyamaN Shimizu
Nov 11, 1991·International Journal of Cancer. Journal International Du Cancer·H MizoguchiM Kuwano
Jul 5, 1989·Journal of the National Cancer Institute·T T Kwok, R M Sutherland

❮ Previous
Next ❯

Citations

Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·F G BarkerK D Aldape
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Ke LiangZhen Fan
Nov 3, 2005·Nature Clinical Practice. Oncology·Carolyn I Sartor
Mar 21, 2007·Cancer Letters·Pinaki R Dutta, Amit Maity
Feb 15, 2018·Metabolites·Carol WardDavid J Argyle
Jan 31, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jiung-Chih Chao, Sheen-Yie Fang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
M HasegawaI Watanabe
The British Journal of Oral & Maxillofacial Surgery
M Sirikumara, M C Gregory
© 2022 Meta ULC. All rights reserved