PMID: 18204193Mar 28, 2008Paper

Correlation of exhaled nitric oxide with nitrogen oxides and selected cytokines in induced sputum of chronic obstructive pulmonary disease patients

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
D ZioraJ Kozielski

Abstract

Assessment of exhaled nitric oxide (eNO) in patients with chronic obstructive pulmonary disease (COPD) provides seemingly conflicting results and the relationships between eNO and other sputum inflammatory mediators are relatively weakly recognized. In the present study we measured eNO in 63 subjects (14 non-smoking healthy controls and 49 COPD stable patients--15 patients at stage 0, 9 patients at stage 1, 16 patients at stage 2, and 9 patients at stage 3). Additionally, concentrations of cytokines (IL-8, TNF-alpha, TGF-beta1, GM-CSF, Eotaxin) and nitrogen oxides (as nitrite or nitrate) (NOs) were measured in induced sputum in these patients. We found that there were no significant differences between the means of either eNO or NOs levels in COPD patients (stage 0-2) and controls. The only significant difference was noted for NOs between the COPD stage 3 patients and controls (9.0+/-1.7 microM vs. 21.1+/-4.8 microM). There was no significant correlation between eNO and sputum NOs. No relationships existed between eNO and the examined cytokine levels, except for a single negative correlation with GM-CSF (r=-0.38, P=0.02). In contrast, NOs correlated positively with IL-8 levels (r=0.51, P<0.01) and IL-8 levels correlated negativ...Continue Reading

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