Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma.

Medical Oncology
Chun-Ta HuangPan-Chyr Yang

Abstract

Epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma are involved in the tumorigenesis and regulation of cell metabolism via Akt signaling. F-18 fluorodeoxyglucose-positron emission tomography ([(18)F]FDG PET), a functional imaging modality, can be used to measure tumor cell metabolism. Thus, in this study, we hypothesize that there exist correlations between EGFR mutation status and [(18)F]FDG uptake of advanced lung adenocarcinoma. From May 2004 to April 2008, patients with stage IIIB or IV lung adenocarcinoma who underwent [(18)F]FDG PET and EGFR mutation analysis before receiving any treatment were eligible to participate in this study. The association of EGFR mutation status with patient characteristics and the SUV(MAX) from the [(18)F]FDG PET was evaluated. Multivariate logistic regression analysis was used to analyze predictors of EGFR mutations. Seventy-seven lung adenocarcinoma patients were included in this study. EGFR mutations were identified in 49 (64%) of the patients. The [(18)F]FDG uptake was significantly higher in EGFR-mutant (mean SUV(MAX) = 10.5 +/- 4.7) than wild-type (8.0 +/- 3.3) lung adenocarcinoma patients (P = 0.008). The median SUV(MAX) was 9.5, and patients with an SUV(MAX) >or= 9...Continue Reading

References

Jan 1, 1984·Image--the Journal of Nursing Scholarship·M Y Lin
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Jun 28, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L J VanuytselG J Kutcher
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Mar 21, 2001·FEBS Letters·E HajduchH S Hundal
May 18, 2001·Nature·P Blume-Jensen, T Hunter
Jan 24, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jin Sook RyuDouglas J Mathisen
Jun 28, 2002·Cancer Cell·John D MinnaAdi F Gazdar
Dec 25, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E MassarelliR S Herbst
Mar 22, 2003·Experimental Cell Research·Robert N JorissenAntony W Burgess
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael P Mac ManusDavid L Ball
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang A WeberMarkus Schwaiger
Jul 31, 2004·Science·Raffaella SordellaJeffrey Settleman
Aug 5, 2004·Journal of the National Cancer Institute·Federico CappuzzoLucio Crinò
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Román Pérez-SolerPhilip Bonomi
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J DowneyValerie Rusch
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ryohei SasakiJames D Cox
May 5, 2005·Journal of the National Cancer Institute·Federico CappuzzoMarileila Varella-Garcia
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Marcelo MamedeTsuneo Saga
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Robert James CerfolioAlfred A Bartolucci
Jun 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Akira InoueToshihiro Nukiwa
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Helen SuWolfgang Weber
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chih-Hsin YangPan-Chyr Yang
Jun 4, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Karen Kelly, Chao Huang
Dec 1, 2000·European Journal of Nuclear Medicine·K HigashiI Yamamoto

❮ Previous
Next ❯

Citations

Nov 7, 2013·Journal of Cancer Research and Clinical Oncology·Hyun Woo ChungYoung So
May 24, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Kai-Hsiung KoHung Chang
Jul 6, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Carlos CaicedoJose Luis Perez Gracia
Aug 27, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chao-Hua ChiuChun-Ming Tsai
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Dec 25, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hongyoon ChoiDong Soo Lee
Mar 16, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Paul M PutoraJoachim Müller
Jun 21, 2016·PET Clinics·Esther MenaRathan M Subramaniam
May 6, 2016·The British Journal of Radiology·Pierre LovinfosseRoland Hustinx
Jan 22, 2015·Clinical Nuclear Medicine·Elaine Yuen Phin LeeMaria Pik Wong
Mar 31, 2015·Nuclear Medicine Communications·Laura GilardiChiara M Grana
Jan 25, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Min YangHongjun Jin
Jan 6, 2021·Radiology·Michal R Tomaszewski, Robert J Gillies
Oct 1, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stephen S F YipHugo J W L Aerts
Dec 24, 2019·Current Radiopharmaceuticals·Silvi TeloStefano Fanti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.