Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Keyur PatelJohn G McHutchison

Abstract

Accurate disease staging in chronic hepatitis C (CHC) infection helps guide treatment and may provide prognostic information. Liver biopsies are invasive, costly, and associated with morbidity. We hypothesized that a noninvasive test of liver fibrosis can accurately stage liver fibrosis. We prospectively evaluated the FIBROSpect II (FSII) biomarker panel versus pathology assessment and a quantitative measure of fibrosis. Liver biopsy specimens and serum were obtained from 252 CHC patients, including 50 posttransplant, from 3 tertiary centers. Biopsy specimens were scored centrally and independently at each site, along with central quantification of fibrosis by digitized morphometry. Serum tests were performed blinded to clinical or histologic evaluation. The mean biopsy specimen length was 1.95 +/- 0.87 cm; prevalence of stage F2 through F4 fibrosis was 77%. Agreement between central and site readings for individual stages was modest (k = 0.674), with concordant readings in 106 of 248 (43%) biopsy specimens. The area under the receiver operating characteristic curve for FSII and morphometry for stages F2 through F4 for concordant biopsy specimens were 0.823 and 0.728, respectively. Sensitivity and specificity for FSII were 83.5...Continue Reading

References

Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F CadranelF Degos
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre BedossaValerie Paradis
Jan 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marie-Christine RousseletUNKNOWN Hepatitis Network 49
Feb 4, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianne ZiolMichel Beaugrand
Mar 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Salvador BenllochJoaquín Berenguer
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul CalèsFrançoise Lunel
Dec 14, 2005·Gastroenterology·Tarik AsselahPatrick Marcellin
Jan 13, 2006·Gastroenterology·Jules L Dienstag, John G McHutchison
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C Rockey, D Montgomery Bissell
Apr 20, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ned SnyderJohn Petersen

❮ Previous
Next ❯

Citations

Aug 19, 2011·BMC Gastroenterology·Ancha BaranovaZobair M Younossi
Oct 22, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Giada SebastianiMario Plebani
Jun 22, 2012·World Journal of Gastroenterology : WJG·Xu-Dong LiuQing-Shou Sheng
Mar 25, 2014·World Journal of Gastroenterology : WJG·Leonardo de Lucca SchiavonRoberto José de Carvalho-Filho
Sep 1, 2008·Expert Opinion on Medical Diagnostics·Richard M LevensonMassimo Loda
Apr 20, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter JarcuskaLubomír Skladaný
Dec 31, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David R NelsonNizar Zein
Dec 17, 2008·Gastroentérologie Clinique Et Biologique·V Leroy
Dec 17, 2008·Gastroentérologie Clinique Et Biologique·T PoynardV Ratziu
Sep 9, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jayant A Talwalkar, Schuyler O Sanderson
May 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dirk J Van LeeuwenAmar P Dhillon
Oct 16, 2015·Clinics in Liver Disease·Anouar Teriaky, Nancy Reau
Feb 20, 2009·Journal of Viral Hepatitis·K J CheungH Van Vlierberghe
Jun 13, 2009·Alimentary Pharmacology & Therapeutics·J O Smith, R K Sterling
Jan 18, 2012·Journal of Viral Hepatitis·G Sebastiani, A Alberti
Oct 30, 2016·Disease-a-month : DM·Eula Plana TetangcoEdgar V Lerma
Sep 5, 2014·European Journal of Gastroenterology & Hepatology·Tomas KollerJuraj Payer
Aug 30, 2014·World Journal of Gastroenterology : WJG·Giada SebastianiKostas Pantopoulos
Jan 29, 2016·World Journal of Gastroenterology : WJG·Pamela ValvaMaria V Preciado
Jul 7, 2021·Journal of Viral Hepatitis·Stefania VarchettaMario U Mondelli
Aug 13, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xiaofei ZhangM Isabel Fiel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Chun-Tao WaiAnna S-F Lok
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Robert J FontanaHALT-C Trial Group
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Indra Neil GuhaWilliam M Rosenberg
© 2021 Meta ULC. All rights reserved