Correlation of findings on transvaginal sonography with serum CA 125 levels

AJR. American Journal of Roentgenology
R N TroianoK J Taylor

Abstract

This study was performed to correlate findings on transvaginal sonography with differential levels of serum CA 125. The study population included 144 patients who underwent transvaginal sonography for suspected pelvic mass and in whom a serum CA 125 level was established as part of the diagnostic workup. Levels of less than 36 U/ml were considered nonelevated; levels equal to or greater than 36 U/ml but less than 50 U/ml were considered mildly elevated; levels of 50-100 U/ml, moderately elevated: and levels greater than 100 U/ml, markedly elevated. Seventy-eight patients had pathologically proven gynecologic disease. Sixty-six patients were followed up with serial sonograms; benign gynecologic disease was diagnosed in 39 of these patients. In the 5-year period included in the study, the patients followed up with serial sonograms were imaged an average of 2.6 times during 2.1 years. Transvaginal sonography had a sensitivity of 97%, a specificity of 97%, and an overall accuracy of 94% for correctly revealing pathologically proven gynecologic disease. Interpreters of the sonograms misdiagnosed no carcinomas, even in patients with nonelevated levels of CA 125. Likewise, no benign lesions were incorrectly interpreted as malignant, e...Continue Reading

Citations

Feb 28, 2006·Cardiovascular and Interventional Radiology·D DukeM J Lee
May 23, 2001·Ultrasound in Medicine & Biology·K J Taylor, P E Schwartz
Aug 27, 2009·BMJ : British Medical Journal·Robin Fox
Mar 1, 2005·Journal of Clinical Pathology·E L MossT M Reynolds
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B. KobalL. Zaletel-Kragelj
Jul 16, 2002·Radiologic Clinics of North America·Stacey A Funt, Lucy E Hann
Feb 15, 2001·The Journal of the American Association of Gynecologic Laparoscopists·L MettlerK Semm
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E. M. LoyerM. J. Fenstermacher

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