Correlation of fundus autofluorescence with spectral-domain optical coherence tomography and vision in diabetic macular edema

Ophthalmology
Hyewon ChungHyung Chan Kim

Abstract

To investigate the correlation between fundus autofluorescence (FAF) and the results of spectral-domain optical coherence tomography (SD-OCT) as well as visual acuity (VA) in patients with diabetic macular edema (DME) and to determine the visual prognostic factors. Retrospective, interventional case series. Sixty-one patients with DME who underwent intravitreal injection of bevacizumab (IVB) as their first treatment. An assessment of VA and FAF and SD-OCT images were obtained before and after IVB (pre- and post-IVB). Foveal FAF was graded on a scale of 1 to 4. The presence or absence of FAF at the foveola was also determined. The association of FAF with VA and the SD-OCT results, including central macular thickness (CMT), outer nuclear layer thickness, the integrity of the external limiting membrane (ELM), and the integrity of the junction between the inner and outer segment of the photoreceptor (IS/OS). Better VA, preservation of the ELM, and IS/OS pre-IVB were associated with better VA post-IVB. Of the types of DME, cystoid macular edema significantly correlated with increased FAF at the foveola. A higher level of FAF was 5.6 times more likely to occur in DME with a defect in IS/OS and 10 times more likely to occur with each ...Continue Reading

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Citations

Mar 16, 2016·Journal of Ophthalmology·Ana M Calvo-MarotoAlejandro Cerviño
Feb 12, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Kaivon Pakzad-VaeziFarzin Forooghian
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May 6, 2016·Journal of Diabetes·Ana M Calvo-MarotoAlejandro Cerviño
Apr 25, 2019·BioMed Research International·Roberta FarciMaurizio Fossarello

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