Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.

PloS One
James B WingAndrew W Heath

Abstract

Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels. The mechanism of this relative loss of humoral protection remains undetermined. In this report we have investigated the relationship between T- and B-cell activation and co-stimulation and the loss of protective antibody titers. We have found that healthy volunteers who lose protective MenC antibody levels one year after receipt of glycoconjugate vaccine exhibit no detectable cellular defect in polyclonal B- or T-cell activation, proliferation or the B-memory pool. This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation.

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Methods Mentioned

BETA
flow cytometry
flowcytometry
Fluorescence

Software Mentioned

FlowJo
Soft Flow
BD FACSArray
FCAP array
FlowJoâ¢
FACSdivaâ¢

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