PMID: 6162268Jan 1, 1980Paper

Correlation of histology and alpha 1-fetoprotein resurgence in rat liver regeneration after experimental injury by galactosamine

Virchows Archiv. A, Pathological Anatomy and Histology
Wolf D Kuhlmann, K Wurster

Abstract

Intraperitoneal injections of galactosamine-HCl in rats were followed by transitory elevations of serum alpha-fetoprotein (AFP) concentrations. These were associated with regeneration of the damaged liver; a maximum of serum AFP was reached on day 4 (2.08 +/- 0.67 microgram/ml). In sera of untreated rats, serum AFP levels were less than 0.1 microgram/ml and no cellular AFP was detected in liver sections. Two days after galactosamine injections, AFP was localized for the first time in the cytoplasm of epithelial cells of bile ducts and canaliculi in portal spaces. The intensity of AFP staining reached a maximum between days 3 and 4. In addition, faint but distinct AFP-positive reactions were seen in the cytoplasm of randomly distributed hepatocytes. After day 5, AFP-staining cells rapidly disappeared. A strong correlation was noted between reappearance of AFP in sera, intensity of epithelial bile duct proliferation and cellular AFP staining.

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Citations

Jul 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·V N BaranovA K Iazova
Aug 22, 2000·Journal of Hepatology·D AlvaroA F Attili
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·W D Kuhlmann
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D RosenbergS Sell
Nov 8, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Keisuke KakisakaYasuhiro Takikawa
Jan 24, 2007·Gastroenterology·Domenico AlvaroGianfranco Alpini
Jun 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L YavorkovskyS Sell
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BlumrichP Steinberg
Dec 17, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shuanglian WangWei-Yang Lu
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·S Sell
Sep 13, 2006·International Journal of Experimental Pathology·Wolf D Kuhlmann, Peter Peschke
Aug 23, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Yijin WangJingmin Zhao
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KogaH Ibayashi

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