Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion-weighted MRI in head and neck squamous cell carcinomas

Head & Neck
Juliette P DriessenMarielle E P Philippens

Abstract

Identification of prognostic patient characteristics in head and neck squamous cell carcinoma (HNSCC) is of great importance. Human papillomavirus (HPV)-positive HNSCCs have favorable response to (chemo)radiotherapy. Apparent diffusion coefficient, derived from diffusion-weighted MRI, has also shown to predict treatment response. The purpose of this study was to evaluate the correlation between HPV status and apparent diffusion coefficient. Seventy-three patients with histologically proven HNSCC were retrospectively analyzed. Mean pretreatment apparent diffusion coefficient was calculated by delineation of total tumor volume on diffusion-weighted MRI. HPV status was analyzed and correlated to apparent diffusion coefficient. Six HNSCCs were HPV-positive. HPV-positive HNSCC showed significantly lower apparent diffusion coefficient compared to HPV-negative. This correlation was independent of other patient characteristics. In HNSCC, positive HPV status correlates with low mean apparent diffusion coefficient. The favorable prognostic value of low pretreatment apparent diffusion coefficient might be partially attributed to patients with a positive HPV status. © 2015 Wiley Periodicals, Inc. Head Neck 38: E613-E618, 2016.

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Citations

Aug 21, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Ann D King, Harriet C Thoeny
Mar 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sae Rom ChungJung Hwan Baek
Apr 21, 2021·Clinical Neuroradiology·Heli J SistonenAntti Markkola
Aug 31, 2021·Seminars in Radiation Oncology·Travis C SalzilloClifton D Fuller

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