Correlation of immune phenotype with IDH mutation in diffuse glioma.

Neuro-oncology
Anna Sophie BerghoffMatthias Preusser

Abstract

Tumor infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1) are targets of immune checkpoint inhibitors. Forty-three World Health Organization (WHO) grade II/III gliomas (39 IDH-mutant [mut], 4 IDH-wildtype [wt]) and 14 IDH-mut glioblastomas (GBM) were analyzed for TIL (CD3+; PD1+) infiltration and PD-L1 expression. Results were compared with the data of a previously published series of 117 IDH-wt glioblastomas. PD-L1 gene expression levels were evaluated in 677 diffuse gliomas grades II-IV from The Cancer Genome Atlas (TCGA) database. TIL and PD-L1 expression were observed in approximately half of WHO grade II/III gliomas. IDH-wt status was associated with significantly higher TIL infiltration and PD-L1 expression among all (grades II-IV) cases (n = 174, P < 0.001) and within the cohort of glioblastomas (n = 131, P < 0.001). In low-grade glioma (LGG) and glioblastoma cohorts of TCGA, significantly higher PD-L1 gene expression levels were evident in IDH-wt compared with IDH-mut samples (LGG: N = 516; P = 1.933e-11, GBM: N = 161; P < 0.009). Lower PD-L1 gene expression was associated with increased promoter methylation (Spearman correlation coefficient -0.36; P < 0.01) in the LGG cohort of TCGA. IDH-mut gliomas h...Continue Reading

References

Apr 12, 2001·Journal of Clinical Epidemiology·R Bender, S Lange
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Nov 12, 2009·Brain Pathology·David CapperAndreas von Deimling
Apr 20, 2010·Cancer Cell·Houtan NoushmehrUNKNOWN Cancer Genome Atlas Research Network
Jun 19, 2010·Nature·Lenny DangShinsan M Su
Jan 18, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna M DahlinRichard Palmqvist
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Dec 24, 2013·Clinical Neuropathology·Anna Sophie BerghoffMatthias Preusser
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
Jul 22, 2014·Nature·Theresa SchumacherMichael Platten
Oct 31, 2014·Neuro-oncology·Anna Sophie BerghoffWolfgang Wick
Apr 8, 2015·Nature Genetics·Hiromichi SuzukiSeishi Ogawa
Jun 20, 2015·Acta Neuropathologica·David E ReussAndreas von Deimling
Jul 18, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jaemoon KohDoo Hyun Chung
Aug 12, 2015·Nature Reviews. Neurology·Matthias PreusserJohn H Sampson
Sep 2, 2015·Neuro-oncology·Edjah K NduomAmy B Heimberger
Nov 7, 2015·CNS Oncology·Adelheid Woehrer, Johannes A Hainfellner
Nov 8, 2015·Cancer Immunology Research·David A ReardonGordon J Freeman
Dec 19, 2015·Cancer Cell·Kensuke TateishiDaniel P Cahill
Dec 25, 2015·Nature·William A FlavahanBradley E Bernstein
Jan 21, 2016·Journal for Immunotherapy of Cancer·Jianda YuanBernard A Fox
Mar 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric BouffetUri Tabori
Apr 17, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Priti S HegdeStefan Evers
Jun 9, 2016·Nature Genetics·Jiguang WangRaul Rabadan
Jul 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer E KimMichael Lim
Jul 13, 2016·British Journal of Cancer·Jung Ho KimGyeong Hoon Kang
Oct 21, 2016·Journal of Neuro-oncology·Anna Sophie BerghoffMatthias Preusser
Aug 16, 2016·The Journal of Clinical Investigation·Adil I DaudMichael D Rosenblum
Aug 19, 2016·Neuro-oncology·Anna S Berghoff, Matthias Preusser
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tiffany G HuynhMari Mino-Kenudson

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Citations

Oct 17, 2017·Neuro-oncology·Felix Sahm, Antje Wick
Nov 15, 2018·Expert Review of Molecular Diagnostics·Alberto PiccaMarc Sanson
Feb 13, 2019·International Journal of Molecular Sciences·Ines UgeleMarina Kreutz
Mar 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bozena KaminskaBartlomiej Gielniewski
Jul 30, 2019·Immunological Reviews·David AkhavanChristine E Brown
Nov 18, 2017·Journal of Neuro-oncology·Kyu Sang LeeGheeyoung Choe
Dec 12, 2019·Journal of Neurology·Feng-Xiang WangMing Guan
Nov 20, 2019·Oncotarget·Shelli R KeslerJohn de Groot
Apr 10, 2020·Future Oncology·Vincenzo Di NunnoAlba Ariela Brandes
Aug 14, 2020·Journal of Neuropathology and Experimental Neurology·Stine Asferg PettersonBjarne Winther Kristensen
Sep 29, 2020·Japanese Journal of Clinical Oncology·Takahide NejoHideho Okada
Jan 29, 2019·Frontiers in Pharmacology·Ruo Qiao ChenXiao Qian Chen
May 16, 2020·Journal of Oncology·Fausta CiccocioppoSebastiano Miscia
May 28, 2020·Journal for Immunotherapy of Cancer·Di ChenLiangfu Zhou
Sep 15, 2020·Oncoimmunology·Leland G RichardsonWilliam T Curry
Oct 28, 2019·Cancers·Jong-Whi Park, Şevin Turcan
Feb 18, 2020·Journal of Cancer Research and Clinical Oncology·Peng LinGang Chen
Oct 19, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Prerana JhaVaishali Suri
Jan 22, 2020·Expert Opinion on Biological Therapy·David B AltshulerMaria G Castro
Sep 16, 2020·Nature Reviews. Drug Discovery·Simon J HoggRicky W Johnstone
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alimu AdilijiangAtsushi Natsume
Jul 2, 2019·Frontiers in Immunology·Xiangfeng ShenZhi-Xiang Xu

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