Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter

Environmental Health Perspectives
John M VeranthGarold S Yost

Abstract

We treated human lung epithelial cells, type BEAS-2B, with 10-80 microg/cm2 of dust from soils and road surfaces in the western United States that contained particulate matter (PM) < 2.5 microm aerodynamic diameter. Cell viability and cytokine secretion responses were measured at 24 hr. Each dust sample is a complex mixture containing particles from different minerals mixed with biogenic and anthropogenic materials. We determined the particle chemical composition using methods based on the U.S. Environmental Protection Agency Speciation Trends Network (STN) and the National Park Service Interagency Monitoring of Protected Visual Environments (IMPROVE) network. The functionally defined carbon fractions reported by the ambient monitoring networks have not been widely used for toxicology studies. The soil-derived PM2.5 from different sites showed a wide range of potency for inducing the release of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in vitro. Univariate regression and multivariate redundancy analysis were used to test for correlation of viability and cytokine release with the concentrations of 40 elements, 7 ions, and 8 carbon fractions. The particles showed positive correlation between IL-6 release and the...Continue Reading

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Jan 8, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·John M VeranthGarold S Yost

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
lavage
bronchoalveolar
X-ray
ELISA

Software Mentioned

JMP
STN
IMPROVE
CANOCO

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