Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects

Vox Sanguinis
Raymond P GoodrichAnthon du P Heyns

Abstract

Changes in in vitro platelet quality parameters during platelet storage are associated with a decrease of in vivo platelet viability after platelet transfusion. Many attempts have been made to identify the most predictable in vitro parameters for in vivo performance. We used a riboflavin-based ultraviolet (UV) light treatment process designed to inactivate pathogens and white blood cell (WBC) contaminants in blood products as a model system in which to study the correlation of in vitro cell quality with in vivo viability. Platelet products (n = 18) were collected by a standard Trima apheresis procedure and treated with one of three dose levels of UV light (0, 7.2 or 12.4 J/ml) in the presence of 50 microm riboflavin. Lactate production, glucose consumption and P-selectin expression, pH, pCO(2), pO(2), hypotonic shock response and swirl were measured during 5 days of platelet storage post-UV/RB treatment. Aliquots of these products were radiolabelled on day 5 of storage and were subsequently used to determine platelet recovery and survival time in autologous subjects. The responses of in vitro cell quality were observed to occur in a UV dose-dependent manner. Lactate production and pH were identified as the parameters most stron...Continue Reading

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Citations

Jul 4, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Maria Adele MastroianniSeyed Ali Mousavi
Jul 23, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Axel Seltsam, Thomas H Müller
Jul 23, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Susanne Marschner, Raymond Goodrich
May 3, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Azucena CastrilloLindsay Rouse
Jun 8, 2007·Journal of Translational Medicine·Florian BihlChristian Brander
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Aug 9, 2011·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Zoran StanojkovićMiodrag Stojanović
Apr 2, 2014·Transfusion Medicine Reviews·Michel PrudentLello Zolla
Nov 29, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Marie E TauszigBirgit S Gathof
Apr 16, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Maria I C Gyongyossy-Issa
Jun 2, 2010·Clinics in Laboratory Medicine·Dana V Devine, Katherine Serrano
Oct 2, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·John McClaskeyChristopher A Tormey
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Nov 27, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Torunn O Apelseth, Tor Hervig
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Jun 15, 2011·Vox Sanguinis·S Panzer, P Jilma
Sep 10, 2014·Journal of Proteomics·Monika DzieciatkowskaKirk C Hansen

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