Correlation of in vivo and ex vivo (1)H-MRI with histology in two severities of mouse spinal cord injury

Frontiers in Neuroanatomy
Harun N NoristaniFlorence E Perrin

Abstract

Spinal cord injury (SCI) is a debilitating neuropathology with no effective treatment. Magnetic resonance imaging (MRI) technology is the only method used to assess the impact of an injury on the structure and function of the human spinal cord. Moreover, in pre-clinical SCI research, MRI is a non-invasive method with great translational potential since it provides relevant longitudinal assessment of anatomical and structural alterations induced by an injury. It is only recently that MRI techniques have been effectively used for the follow-up of SCI in rodents. However, the vast majority of these studies have been carried out on rats and when conducted in mice, the contusion injury model was predominantly chosen. Due to the remarkable potential of transgenic mice for studying the pathophysiology of SCI, we examined the use of both in and ex vivo (1)H-MRI (9.4 T) in two severities of the mouse SCI (hemisection and over-hemisection) and documented their correlation with histological assessments. We demonstrated that a clear distinction between the two injury severities is possible using in and ex vivo (1)H-MRI and that ex vivo MR images closely correlate with histology. Moreover, tissue modifications at a remote location from the ...Continue Reading

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Citations

Apr 27, 2016·Advanced Healthcare Materials·Dongfei LiuJin Fan
Oct 27, 2018·Journal of Neuropathology and Experimental Neurology·Juan Eugenio IglesiasJanice L Holton
Nov 6, 2018·Frontiers in Cellular Neuroscience·Yannick Nicolas GerberFlorence Evelyne Perrin
Oct 8, 2016·Molecular Neurodegeneration·Harun Najib NoristaniFlorence Evelyne Perrin
Aug 5, 2017·Frontiers in Aging Neuroscience·Harun N NoristaniFlorence E Perrin
Nov 29, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Marine Le CorreFlorence E Perrin
Jan 29, 2019·Neural Regeneration Research·Harun Najib Noristani, Florence Evelyne Perrin
Apr 20, 2017·Frontiers in Molecular Neuroscience·Harun N NoristaniFlorence E Perrin

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