Correlation of increased Th17/Treg cell ratio with endoplasmic reticulum stress in chronic kidney disease

Medicine
Xiaojing ZhuYan Ou

Abstract

To investigate the relationship between the regulatory immune network and endoplasmic reticulum stress (ERS) in patients with different stages of chronic kidney disease (CKD).A total of 91 patients diagnosed with CKD were divided into different groups according to the stage of disease and treatment with hemodialysis (HD) or peritoneal dialysis (PD). Routine blood and biochemical tests were performed in patients in the different CKD groups and in healthy controls (n = 20). The frequencies of T helper type 17 (Th17) and regulatory T (Treg) cells in the overall T cell population were measured by flow cytometric analysis. Levels of Th17 cell (IL-17) and Treg cell (IL-10) cytokines and the ERS markers CCAAT-enhancer-binding protein homologous protein (CHOP) and glucose-regulated protein 78 (GRP78) were measured by enzyme-linked immunosorbent assay in serum samples collected from controls and patients. Correlations between each parameter and serum creatinine were analyzed by Spearman rank correlation and regression test.CKD stage showed a positive correlation with serum creatinine level, and increased and decreased percentages of Th17 and Treg cells, respectively, reflected in an increased Th17/Treg cell ratio. Consistent with this, ...Continue Reading

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Citations

Sep 30, 2020·Biomolecules·Vanessa MarchantMarta Ruiz-Ortega
Dec 1, 2021·Journal of Diabetes Investigation·Lingyun KongElif I Ekinci

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Methods Mentioned

BETA
density gradient centrifugation
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS
FlowJo Data Analysis

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