Correlation of integrin beta3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma.

World Journal of Gastroenterology : WJG
Shu-Guang LiChun-Yu Niu

Abstract

To investigate integrin beta3 mRNA and vascular endothelial growth factor (VEGF) protein expression in gastric carcinoma, and its correlation with microvascular density, growth-pattern, invasion, metastasis and prognosis. In situ hybridization(ISH) of integrin beta3 mRNA and immunohistochemistry of VEGF and CD34 protein were performed on samples from 118 patients with gastric cancer. The positive rate of integrin beta3 mRNA in non-tumor gastric mucosa (20%) was significantly lower than that of the gastric cancer tissue (52.5%, c2 = 10.20, P < 0.01). In patients of infiltrating type, stage T(3)-T(4), vessel invasion, lymphatic metastasis, hepatic or peritoneal metastasis, the positive expression rates of integrin beta3 mRNA were significantly higher than those in patients of expanding type (P < 0.01), stage T(1)-T(2) (P < 0.01), non-vessel invasion (P < 0.01), without lymphatic metastasis (P < 0.01), without hepatic and peritoneal metastasis (P < 0.01), respectively. In patients of infiltrating type, stage T(3)-T(4), vessel invasion, lymphatic metastasis, hepatic or peritoneal metastasis, the positive expression rates of VEGF protein were significantly higher than those in patients of expanding type (P < 0.01), stage T(1)-T(2) (...Continue Reading

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Citations

Jan 15, 2010·Journal of Ocular Biology, Diseases, and Informatics·Jing CuiPeter Baciu
Dec 24, 2008·Journal of Cancer Research and Clinical Oncology·Jie ChenMaosun Fu
Sep 16, 2011·Journal of Cancer Research and Clinical Oncology·Jing ChenXiufeng Pang
Nov 17, 2010·Cancer Investigation·Abby B SiegelAlfred I Neugut
Jun 12, 2013·The Journal of Pharmacology and Experimental Therapeutics·Shundong JiSarah R Mudd
Aug 12, 2020·Cancer Metastasis Reviews·Leela Rani AvulaChristine Alewine
Jun 17, 2011·Molecular Biology Reports·Na LiHe-long Zhang
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anand VeeravaguXiaoyuan Chen

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