Correlation of lactoferrin with neutrophilic inflammation in body fluids.

Clinical and Diagnostic Laboratory Immunology
C A MartinsR L Guerrant

Abstract

We have reported that lactoferrin, a 77-kDa iron-binding glycoprotein found in secondary neutrophil granules, provides a useful marker of fecal leukocytes in fecal specimens from patients with inflammatory diarrhea (R. L. Guerrant, V. Araujo, E. Soares, K. Kotloff, A. A. M. Lima, W. H. Cooper, and A. G. Lee, J. Clin. Microbiol. 30:1238-1242, 1992). In order to determine the usefulness of this marker of neutrophilic inflammation in different body fluids, we examined blood, gingival swabs, sputum, and saliva using antilactoferrin antibodies (lactoferrin latex agglutination [LFLA]). LFLA titers in whole blood samples were < or = 1:4 in all eight samples from patients with neutropenia (absolute neutrophil count [ANC] = < 150 polymorphonuclear cells [PMNs] per microliter), < or = 1:8 in samples from 13 individuals with moderate leukocyte counts (ANC = 150 to 8,000), and 1:8 to 1:32 in samples from six patients with neutrophilia (ANC > 8,000). While the overlap precludes a useful role in the identification of neutropenia, these data confirm that lactoferrin titers of > 1:100 indeed indicate inflammation in fluid specimens. On quantitative elution of lactoferrin from gingival swabs, all 7 patients with dental plaque had titers of 1:20...Continue Reading

References

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Citations

Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B E BritiganA M Krieg
Jul 26, 2015·BMC Veterinary Research·Annette ProhlPetra Reinhold
Nov 20, 1998·Clinical and Experimental Immunology·A C Muller KoboldJ W Tervaert
Oct 11, 2016·Journal of Gastroenterology and Hepatology·Robert N LopezAndrew S Day
Jul 21, 2012·Journal of Clinical Pathology·Roy A Sherwood
Aug 5, 2017·Expert Review of Molecular Diagnostics·Andrew S DayDaniel A Lemberg
Aug 5, 2009·Internal Medicine·Tetsuo HayakawaHiroshi Ishiguro
Jul 14, 2006·International Journal of Colorectal Disease·Renata D'IncàGiacomo Carlo Sturniolo

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