Correlation of liver stiffness and histological features in healthy persons and in patients with occult hepatitis B, chronic active hepatitis B, or hepatitis B cirrhosis

The American Journal of Gastroenterology
James FungMan-Fung Yuen

Abstract

Liver stiffness measurement using transient elastography has become a popular tool to assess liver fibrosis. The aim of this study was to determine liver stiffness values and histological features in healthy subjects and in patients with chronic hepatitis B (CHB). A total of 157 people were included (28 healthy subjects and 18 patients with occult hepatitis B infection, 102 with active CHB, and 9 with end-stage hepatitis B cirrhosis). Histology and liver stiffness measurements were obtained from all patients. The median liver stiffness in healthy subjects and in occult hepatitis B, active hepatitis B, and end-stage cirrhosis patients was 4.6, 4.2, 8.7, and 33.8 kPa, respectively. In healthy subjects and in patients with occult hepatitis B infection, none had significant fibrosis on histology, and all had liver stiffness <7.2 kPa. In patients with active CHB, 32 (31%) had liver stiffness >11.0 kPa, but only four (12%) had cirrhosis on histology. Using liver stiffness to predict cirrhosis in this group had a sensitivity of 100%, a specificity of 69%, a positive predictive value of 10%, and a negative predictive value of 100%. All nine patients with end-stage liver cirrhosis had liver stiffness >11.0 kPa. The overall area under th...Continue Reading

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Citations

Nov 5, 2010·World Journal of Gastroenterology : WJG·Seung Up KimSang Hoon Ahn
Apr 8, 2011·World Journal of Gastroenterology : WJG·Miriam RomeroJavier García-Samaniego
Jan 16, 2016·International Journal of Hepatology·Hugo PerazzoRodolfo Castro
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Aug 16, 2012·Clinical and Molecular Hepatology·Kyu Sik Jung, Seung Up Kim
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