Correlation of maternal A1c with glucose infusion rate requirements in the newborn

Journal of Neonatal-perinatal Medicine
K VeceraE Larumbe

Abstract

Fetal hyperinsulinemia and neonatal hyperglycemia are complications of poor maternal glycemic control and may result in increased glucose infusion rate (GIR) requirements in infants of diabetic mothers (IDMs). The objectives of this study were to correlate maternal A1c levels with GIR requirements in IDMs, establish an A1c threshold predictive for GIR requirements, and identify associations between A1c levels and complications in IDMs. A retrospective review of paired maternal A1c values and GIR requirements of IDMs were compared via logistic regression analysis. A likelihood ratio was calculated to correlate A1c levels with GIR requirements, and identify a maternal A1c threshold. Increasing A1c values were significantly correlated with GIR≥5 mg/kg/min (OR, 1.37; 95% CI 1.04-1.79, p = 0.021). Macrosomia was the most frequent complication (OR, 1.31; 95% CI 1.04-1.67, p = 0.022) and A1c > 6.8% was predictive for increased GIR requirements. Increased A1c values were significantly associated with GIR requirements≥5 mg/kg/min. Increased maternal A1c is significantly associated with complications in newborns, specifically macrosomia. A maternal A1c of 6.8% was identified as a threshold predictive of increased GIR requirements.

References

Oct 9, 2002·European Journal of Endocrinology·P Robert J GallasWilmar M Wiersinga
Mar 20, 2003·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·Ruth E K Stein, Ellen Johnson Silver
May 26, 2004·Pediatric Clinics of North America·Joan L Nold, Michael K Georgieff
Jun 14, 2005·The New England Journal of Medicine·Caroline A CrowtherUNKNOWN Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS) Trial Group
May 31, 2007·Diabetes Care·William H HermanUNKNOWN Diabetes Prevention Program Research Group
Dec 26, 2007·Acta Obstetricia Et Gynecologica Scandinavica·Dorte M JensenPeter Damm
May 9, 2008·The New England Journal of Medicine·UNKNOWN HAPO Study Cooperative Research GroupDavid A Sacks
Mar 12, 2009·The Journal of Clinical Endocrinology and Metabolism·William H HermanSherry Martin
Oct 3, 2009·The New England Journal of Medicine·Mark B LandonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Mar 2, 2010·Diabetes Care·UNKNOWN International Association of Diabetes and Pregnancy Study Groups Consensus PanelMaria Ines Schmidt
Nov 19, 2011·Current Diabetes Reports·William W Hay
Oct 8, 2013·Journal of Diabetes and Its Complications·Alex FongDotun Ogunyemi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
SGA
Cesarean section

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Muhammad AlamS M Akhtar
Clinical Obstetrics and Gynecology
A Ferber
© 2022 Meta ULC. All rights reserved