Correlation of microRNA-10b upregulation and poor prognosis in human gliomas

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yuchen JiHuancong Zuo

Abstract

The aim of this study was to detect the association between the microRNA-10b (miR-10b) expression level and prognosis in glioma patients. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to measure the expression of miR-10b levels in different-grade glioma tissues and normal brain tissues. The relationship between miR-10b expression levels and clinical pathological characteristics was statistically analyzed. The influence of miR-10b on survival of glioma patients was also analyzed. As a result, miR-10b expression levels in glioma tissues were significantly increased compared to those of normal brain tissues (p < 0.001). And the increased expression levels were associated with the advanced glioma grade (p < 0.001) and larger tumor size (p < 0.001). Moreover, the results of the Kaplan-Meier survival curve indicated that overall survival (OS) and progression-free survival (PFS) were significantly poorer in the high-expression-level group than those in the low-expression-level group (p < 0.001). Finally, the results of the multivariate Cox regression model indicated that the miR-10b expression level was an independent prognostic factor for glioma patients. Taken together, these findings offer convincing ...Continue Reading

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Apr 1, 2017·Journal of Clinical Pathology·Heba W Z KhellaGeorge M Yousef
Sep 8, 2018·Journal of Cellular Physiology·Yi ZhangHua-Jun Wu
Dec 3, 2016·Molecular Neurobiology·Ravindra Pramod DeshpandePhanithi Prakash Babu
Mar 15, 2019·Experimental and Therapeutic Medicine·Qiang DongYawen Pan
Apr 30, 2019·BioMed Research International·Yanming ZhangLijun Hou

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