Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer

Genetics and Molecular Research : GMR
Y B MaB M Shi

Abstract

MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the associations between miR-494 expression and clinicopathological features. The survival correlations were analyzed by using the Kaplan-Meier method and Cox proportional hazards model. The level of miR-494 expression was significantly downregulated in pancreatic cancer tissues (mean relative expression level ± SD, 0.48 ± 0.11) as compared to matched adjacent normal tissues (1.80 ± 0.28, P < 0.05). We found significant correlations between the miR-494 expression levels and TNM stage (P = 0.009), lymphatic invasion (P = 0.036), vascular invasion (P = 0.011), distant metastasis (P = 0.007), and tumor grade (P = 0.031). Pancreatic cancer patients with a low miR-494 expression level had a shorter overall survival than those with a high miR-494 expression level (P < 0.05). Reduced miR-494 expression in pancreatic cancer tissues is correlated with tumor...Continue Reading

Citations

Jan 6, 2017·Cell Death & Disease·Meng-Na ZhanQian Zhao
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sven H LoosenTom Luedde
Jan 10, 2018·Journal of Cellular Biochemistry·Yongbiao MaBaomin Shi
Dec 21, 2019·World Journal of Gastroenterology : WJG·Zheng-Lin OuYe-Bin Lu
Mar 7, 2020·Scientific Reports·Marianne S AndresenGrethe Skretting
Apr 21, 2020·Cancer Management and Research·Roshanak ShamsJosé M Padrón
Oct 11, 2017·Molecular Medicine Reports·Wei YuanZhongliang Deng
Mar 7, 2021·Journal of Personalized Medicine·Beste TuranliRaghu Sinha

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