PMID: 18710621Aug 20, 2008Paper

Correlation of MRI features to histopathologic grade of soft tissue sarcoma

Ai zheng = Aizheng = Chinese journal of cancer
Qing-yu LiuBiling Liang

Abstract

Peripheral tumor growth pattern plays an important role in the local recurrence and metastases of soft tissue sarcoma. This study was to determine the peripheral growth pattern of soft tissue sarcoma by magnetic resonance imaging (MRI), explore its correlation to histological grade, and assess biological features of soft tissue sarcoma before operation. MRI was performed in 59 patients with soft tissue sarcoma. T1- and T2-weighted images were obtained using a spin-echo (SE) pulse sequence. Tumor margin, peritumoral high signal intensity sign and peritumoral low signal intensity capsule-like sign were evaluated on MR images. All patients were confirmed and graded by histopathology. The histological grade of soft tissue sarcoma was closely related to the margin appearance (P<0.05): the margin was well defined in 60.0% grade I tumors, and poorly defined in 60.0% grade III tumors. No significant difference in the occurrence rates of peritumoral high signal intensity sign and peritumoral low signal intensity capsule-like sign was found between grade II and grade III tumors (P>0.05). The occurrence rate of peritumoral high signal intensity sign was significant lower and that of peritumoral low signal intensity capsule-like sign was s...Continue Reading

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