Abstract
Recent studies have revealed that Musashi-1 and Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) were putative stem cell genes. The epidermal growth factor receptor (EGFR) has also been extensively studied; it was known as an oncogenic driver in cancers. Overexpressions of Musashi-1, EGFR, and Lgr5 have been reported in some tumor tissues and cell lines. In this study, we used immunohistochemical analysis to investigate the expression pattern of Musashi-1, Lgr5, and pEGFR in 38 small intestinal adenocarcinomas (SIAs) resection specimens, 20 matched normal specimens and tried to analyze the correlations among them. The positive rate of Musashi-1, Lgr5, and pEGFR in SIAs, respectively, was 71 % (27/38), 55 % (21/38), and 45 % (17/38). Compared with the adjacent normal small intestinal mucosa, Musashi-1, Lgr5, and pEGFR protein were overexpressed in SIAs (P< 0.05). Furthermore, Musashi-1 and Lgr5 expressions were significantly correlated with the depth of wall invasion (P = 0.0011, P = 0.0017, respectively). Musashi-1 expression was closely correlated with Lgr5 (P = 0.015, r = 0.392). However, pEGFR expression was not associated with age, gender, tumor size, differentiation, depth of invasion, lymphatic metastasi...Continue Reading
References
Jan 1, 1984·Cancer·D JigyasuJ R Stroehlein
Jun 27, 1998·Biochemical and Biophysical Research Communications·T McDonaldQ Liu
Dec 14, 1999·Cancer·J R HoweC Scott-Conner
Apr 3, 2001·Glia·M TodaK Uyemura
Jun 11, 2002·Biochemical and Biophysical Research Communications·Hong-Jin ShuSumio Kawata
Feb 1, 2003·Differentiation; Research in Biological Diversity·Christopher S PottenHideyuki Okano
Mar 22, 2003·Experimental Cell Research·Carlos L Arteaga
Aug 20, 2003·Digestive Diseases and Sciences·Satoshi NishimuraShoji Mitsufuji
Jul 27, 2004·Cancer·Bouthaina S DabajaJaffer Ajani
Oct 29, 2004·Molecular and Cellular Biology·Hiroki MoritaAaron J W Hsueh
Dec 27, 2005·Gene·Nicola NormannoDavid S Salomon
Aug 8, 2006·Biochimica Et Biophysica Acta·Sinto SebastianAngelo Paradiso
Nov 24, 2006·Nature·Lucia Ricci-VitianiRuggero De Maria
Nov 24, 2006·Nature·Catherine A O'BrienJohn E Dick
Mar 16, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·P Czaykowski, D Hui
Jun 29, 2007·The International Journal of Biochemistry & Cell Biology·Roberto BiancoGiampaolo Tortora
Aug 3, 2007·The Journal of Clinical Investigation·Hongtao ZhangMark I Greene
Aug 22, 2007·The Journal of Pathology·A SchulenburgH Ulrich-Pur
Oct 16, 2007·Nature·Nick BarkerHans Clevers
Apr 19, 2008·BMC Cancer·Feng YeHuaizeng Chen
May 13, 2008·Gastroenterology·Sripathi M SurebanCourtney W Houchen
Jul 19, 2008·Brain Pathology·Florian A SiebzehnrublIngmar Blümcke
Jul 22, 2008·Journal of Anatomy·Robert K Montgomery, David T Breault
Nov 26, 2008·TheScientificWorldJournal·Laren BeckerHiroshi Mashimo
Dec 17, 2008·International Journal of Cancer. Journal International Du Cancer·Peter ChuRobert J Peach
Apr 28, 2009·Developmental Biology·Marie Isabelle GarciaGilbert Vassart
Jun 25, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L BeckerH Mashimo
Aug 29, 2009·International Journal of Colorectal Disease·Li-Fang FanQiong-Fang Yu
Oct 8, 2009·Cancer Research·Joseph E CarpentinoEmina H Huang
Feb 5, 2010·Oncology·Georg Lurje, Heinz-Josef Lenz
Apr 14, 2010·Cancer Science·Hiroshi UchidaMichiie Sakamoto
Apr 27, 2010·Gastroenterology·Nick Barker, Hans Clevers
Apr 28, 2010·Gastroenterology·Matilde TodaroGiorgio Stassi
May 13, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y V BobryshevR V N Lord
Sep 10, 2010·Gastroenterology·Trevor G LevinMelissa H Wong
Sep 10, 2010·Journal of Cell Science·Amelie RezzaMichelina Plateroti
Sep 17, 2010·Nature·Adan AguirreVittorio Gallo
May 31, 2011·BMC Cancer·Dong Hoe KooTae Won Kim
Aug 11, 2011·PloS One·Francesca WalkerAntony W Burgess
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 13, 2012·Cancer Epidemiology·Yunxia LuJesper Lagergren
May 16, 2012·Journal of Gastroenterology and Hepatology·Junko KurodaYuichi Yamashita
Aug 29, 2012·Cell Proliferation·Y FengL Xia
Nov 17, 2012·World Journal of Surgical Oncology·Xiao-Song WuLin Chen
Dec 26, 2012·Oral Oncology·Aymee PerezElizabeth J Franzmann
Jan 30, 2013·Pathology International·Kazuhiro YamanoiMichiie Sakamoto
Nov 28, 2013·Carcinogenesis·Daniela HirschTimo Gaiser
Apr 3, 2014·International Journal of Oncology·Shuang Li, Qin Li
Citations
Jan 9, 2019·SLAS Discovery·Vito Giuseppe D'AgostinoValentina Adami
Aug 12, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Junji MitsushitaAkira Tanaka
May 7, 2019·International Journal of Molecular Medicine·Chen-Fei WangYu-Nong Wu
May 20, 2017·Oncology Letters·Zhangxuan ShouJiong Yao
May 31, 2018·British Journal of Cancer·R G MorganA C Williams
Jul 26, 2016·Molecular and Clinical Oncology·Xiaohan ZhangJiangchao Li
Dec 3, 2020·Biology·O CrendeJ R Pineda
Mar 21, 2021·Cancer Research·Carla FrauMichelina Plateroti