Correlation of needle core biopsy with excision histology in screen-detected B3 lesions: the Merrion Breast Screening Unit experience

Journal of Clinical Pathology
B D HayesCecily Quinn

Abstract

Needle core biopsy (NCB) is a widely-used technique for non-operative evaluation of screen-detected breast lesions. Although most NCBs are B2 (benign) or B5 (malignant), some fall into the B3 category of "uncertain malignant potential". This study aims to categorise the lesions prompting a B3 NCB in the Merrion Breast Screening Unit, and establish the incidence of malignancy on subsequent excision biopsy. Patients attending the Merrion Breast Screening Unit in Dublin between 2000 and 2008 who had a B3 NCB were identified. The NCB pathology reports were reviewed and the diagnosis correlated with excision histology; the latter was classified as benign, atypical or malignant. Lesion-specific positive predictive values (PPVs) for malignancy were derived. 141 patients with a B3 NCB were identified. The most frequent lesions on NCB were radial scar (RS; n = 57), atypical intraductal epithelial proliferation (AIDEP; n = 25) and papillary lesion (n = 24). The final diagnosis was malignant in 22 patients (16%), atypical in 40 (28%) and benign in 79 (56%). Two of the patients with a malignant diagnosis had invasive carcinoma. The lesion-specific PPVs were: lobular neoplasia 50%, AIDEP 32%, columnar cell lesion with atypia 12.5%, RS 12.3%...Continue Reading

Citations

Oct 13, 2011·Annals of Surgery·Anoek H J Verschuur-MaesPaul J van Diest
Jul 25, 2012·AJR. American Journal of Roentgenology·Viviana LonderoFrancesco Sardanelli
Jun 19, 2013·Annals of Diagnostic Pathology·Francisco Ferro de BeçaIsabel Amendoeira
Aug 20, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kelly L MooneySophia K Apple
Jul 1, 2018·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Yoav AmitaiOrit Golan
Jan 31, 2015·The American Journal of Surgical Pathology·Niamh ConlonAdriana D Corben
Oct 21, 2016·Clinical Obstetrics and Gynecology·Brian Orr, Joseph L Kelley
Aug 18, 2018·BMC Cancer·Christiane Richter-EhrensteinTilman Ehrenstein
Feb 7, 2020·Insights Into Imaging·Ulrich BickUNKNOWN European Society of Breast Imaging (EUSOBI), with language review by Europa Donna–The European Breast Cancer Coalition
Jan 14, 2020·Annals of Diagnostic Pathology·Gorana GašljevićJanez Žgajnar
Aug 31, 2020·Journal of the American College of Radiology : JACR·Mariam N ShehataKathryn P Lowry

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