Correlation of NO metabolites and 8-iso-prostaglandin F2a with periventricular hyperintensity severity

Arteriosclerosis, Thrombosis, and Vascular Biology
Hiroshi ShibataShotai Kobayashi

Abstract

Oxidative stress and NO are thought to play important roles in arteriosclerosis pathogenesis, a major cause of white matter lesions in the brain. Therefore, we examined whether NO metabolites (NOx) and 8-iso-prostaglandin F(2alpha) (IsoP) levels in vivo correlated with the severity of periventricular hyperintensity (PVH) to evaluate potential roles of oxidative stress and NO in white matter lesions. Participants (687 males and 528 females) of a health-screening examination were recruited into the study. The plasma NOx and urinary IsoP levels were measured using the Griess method and ELISA, respectively. PVH was diagnosed on the basis of MRIs. In nonparametric univariate trend analyses, plasma NOx as well as aging, presence of hypertension and of lacunes, mean blood pressure, and high-density lipoprotein cholesterol showed highly significant monotone correlation with PVH severity (P</=0.01). By the multivariate ordinal regression analysis, the plasma NOx (P=0.002) and urinary IsoP (P=0.01) levels were found to be independent factors influencing the severity of PVH together with aging (P<0.001), presence of hypertension (P<0.001) and lacunes (P<0.001), and mean blood pressure (P=0.001). Oxidative stress and NO have a close correl...Continue Reading

References

Apr 17, 1995·Biochemical and Biophysical Research Communications·P RhodesP ] Rhodes PM [corrected to Rhodes
Dec 12, 1997·Journal of the Neurological Sciences·R SchmidtH Esterbauer
May 16, 1998·Biochemical and Biophysical Research Communications·T TsukadaJ Igari
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·C Kitiyakara, C S Wilcox
Jun 29, 2000·Journal of Hypertension·N S DhallaT Netticadan
Jan 26, 2002·Cerebrovascular Diseases·Yeu-Jhy ChangShinn-Kuang Lin
Mar 20, 2002·Cerebrovascular Diseases·Elisabet Englund
Nov 16, 2002·Circulation Research·Sean P DidionFrank M Faraci
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Seinosuke KawashimaMitsuhiro Yokoyama
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Sebastian WolfrumJames K Liao
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·John F KeaneyUNKNOWN Framingham Study
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·Sonia BraultSylvain Chemtob
Sep 6, 2003·Journal of the American College of Cardiology·Ernesto L Schiffrin, Rhian M Touyz

❮ Previous
Next ❯

Citations

Mar 25, 2009·Journal of Clinical Biochemistry and Nutrition·Noriko SakanoKeiki Ogino
Jun 4, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hazel Mae A AbrahamWilliam B White
Dec 6, 2008·American Journal of Hypertension·Yoshitomo NotsuJunichi Masuda
Feb 11, 2009·Free Radical Research·Noriko SakanoKeiki Ogino
Aug 28, 2013·Hypertension·Giuseppe Faraco, Costantino Iadecola
Jan 5, 2006·Critical Reviews in Clinical Laboratory Sciences·Teresa M Seccia, Gian Paolo Rossi
Oct 15, 2010·Free Radical Research·Keiki OginoDa-Hong Wang
Dec 17, 2015·Geriatrics & Gerontology International·Yoshiaki Tamura, Atsushi Araki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.