Correlation of oesophageal acid exposure with Barrett's oesophagus length

Gut
Ronnie FassR Sampliner

Abstract

Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient. To determine if there is a correlation between oesophageal acid exposure and the length of Barrett's mucosa. We also compared the extent of oesophageal acid exposure between patients with short segment (SSBE) and long segment (LSBE) Barrett's oesophagus. Twenty seven patients with Barrett's oesophagus were recruited prospectively into the study from the outpatient gastroenterology clinic at the Southern Arizona VA Health Care System. Diagnosis of Barrett's oesophagus and its anatomical characteristics were determined during upper endoscopy. Ambulatory 24 hour oesophageal pH monitoring assessed the extent of oesophageal acid exposure. There was a significant correlation between per cent total time pH less than 4 and length of Barrett's mucosa (r=0.6234, p=0.0005). In addition, there was a significant correlation between per cent upright and supine time pH less than 4 and length of Barrett's mucosa (r=0.5847, p=0.0014 and r=0.6265 p=0.0006, respectively). Patients with SSBE had significantly less oesophageal ac...Continue Reading

References

Oct 1, 1976·Annals of Surgery·T R DemeesterD B Skinner
Mar 23, 1991·JAMA : the Journal of the American Medical Association·W J BlotJ F Fraumeni
Aug 7, 1986·The New England Journal of Medicine·S J Spechler, R K Goyal
Aug 9, 1995·JAMA : the Journal of the American Medical Association·W H ChowJ F Fraumeni
Nov 1, 1996·The Journal of Clinical Investigation·R C FitzgeraldG Triadafilopoulos
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·B T CooperT H Iqbal
Jul 27, 1999·Gastroenterology·R Ouatu-LascarG Triadafilopoulos
Apr 14, 2000·The American Journal of Gastroenterology·P J KlinglerK R DeVault

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Citations

Apr 9, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A H HölscherP Malfertheiner
Nov 18, 2006·Surgical Endoscopy·L BierthoJ Weerts
Sep 13, 2006·Digestive Diseases and Sciences·Melissa P UptonHelen M Shields
May 26, 2009·Current Gastroenterology Reports·Ronnie Fass
Jul 25, 2007·Gastroentérologie Clinique Et Biologique·Mickael JegoMichel Robaszkiewicz
Apr 25, 2003·Critical Reviews in Oncology/hematology·Massimo ConioRosangela Filiberti
Apr 7, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hashem B El-SeragRichard E Sampliner
Feb 5, 2011·Nature Reviews. Gastroenterology & Hepatology·Tiberiu HershcoviciRonnie Fass
Jan 8, 2008·Oncogene·M Fukata, M T Abreu
Mar 29, 2003·ANZ Journal of Surgery·Reginald V N Lord
Jun 15, 2012·Journal of Gastroenterology and Hepatology·Juliana AndriciGuy D Eslick
Jan 18, 2006·BMJ : British Medical Journal·Mark Fox, Ian Forgacs
Jan 29, 2011·World Journal of Gastroenterology : WJG·Anne L KrarupAsbjørn M Drewes
Mar 5, 2014·The American Journal of Gastroenterology·Helen G ColemanBrian T Johnston
Dec 25, 2008·Journal of Gastroenterology·Koichi OkitaYoshikazu Kinoshita
Apr 7, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Michiko Otsuki
Jun 1, 2009·Clinical Journal of Gastroenterology·Tomoyuki KoikeTooru Shimosegawa
May 29, 2012·Scandinavian Journal of Gastroenterology·Evanthia ZampeliSpiros D Ladas
Jun 29, 2006·Scandinavian Journal of Gastroenterology·Yuji AmanoYoshikazu Kinoshita
Jul 11, 2009·The American Journal of the Medical Sciences·Joel E Richter
Dec 4, 2010·Best Practice & Research. Clinical Gastroenterology·Afrin Kamal, Michael F Vaezi
Mar 10, 2009·Lancet·Nicholas J Shaheen, Joel E Richter
Aug 5, 2008·Gastrointestinal Endoscopy Clinics of North America·Rami J Badreddine, Kenneth K Wang
Nov 5, 2005·Alimentary Pharmacology & Therapeutics·D J SteinR E Sampliner
Sep 27, 2005·Alimentary Pharmacology & Therapeutics·S WaniP Sharma
Jul 20, 2004·The Journal of Pathology·Gerhard FallerThomas Brabletz
Apr 21, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J BredenoordA J P M Smout
Jun 12, 2004·Alimentary Pharmacology & Therapeutics·H B El-SeragR E Sampliner
Aug 31, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R DickmanR Fass
Sep 21, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R DickmanR Fass
Sep 29, 2011·Annals of the New York Academy of Sciences·Joel E RichterRichard H Hunt
Jun 19, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E SavarinoV Savarino
Sep 26, 2006·Best Practice & Research. Clinical Gastroenterology·Paul A Atherfold, Janusz A Jankowski
Apr 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M FrazzoniV Savarino
Aug 15, 2003·Gastrointestinal Endoscopy Clinics of North America·M Brian Fennerty
Oct 21, 2014·Alimentary Pharmacology & Therapeutics·J AbdallahR Fass

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