Correlation of oral glucose tolerance test-derived estimates of insulin sensitivity with insulin clamp measurements in an African-American cohort

Metabolism: Clinical and Experimental
Cynthia ChengBonita E Falkner

Abstract

The purpose of this study was to determine which measures obtained from an oral glucose tolerance test (OGTT) are the best estimates of insulin sensitivity measured directly using the euglycemic hyperinsulinemic clamp procedure. Data were examined from a study conducted on 307 young adult African-American men and women. An OGTT with insulin measurements was conducted after a 12-hour overnight fast. The euglycemic hyperinsulinemic clamp was used to measure insulin-stimulated glucose uptake (M) directly. Pearson's correlation analyses were performed to examine the relationship of OGTT-derived parameters with insulin sensitivity measured using the clamp. There were consistent statistically significant correlations between calculated estimates of insulin sensitivity (fasting insulin/fasting glucose, summed insulin/summed glucose, homeostasis model assessment [HOMA], Quantitative Insulin Sensitivity Check Index [QUICKI]) with insulin sensitivity measured by the insulin clamp (P <.001). The calculated estimates that correlated most strongly with clamp measured insulin sensitivity were QUICKI and the logarithm of summed insulin during the OGTT. These data indicate that fasting and OGTT-derived plasma insulin and glucose concentrations...Continue Reading

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Citations

Jul 12, 2007·Annals of Nutrition & Metabolism·Mianyun WuTao Lu
Mar 18, 2011·The American Journal of the Medical Sciences·Maria P Martinez CantarinBonita Falkner
Mar 26, 2011·Diabetes & Metabolism·B Antuna-PuenteJ-P Bastard
Aug 12, 2008·Journal of Sleep Research·Mark R ZielinskiShawn D Youngstedt
May 12, 2006·The Journal of Clinical Hypertension·Bonita FalknerHarvey Kushner
Nov 24, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R S RaoS Kini
Mar 21, 2006·Metabolism: Clinical and Experimental·Cynthia ChengBonita E Falkner
Apr 13, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Lucas NtyintyaneGeoffrey Gill
Jul 11, 2018·Hypertension·Brenda MendizábalJoseph T Flynn

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