Correlation of oxidation-reduction potential with hormones, semen parameters and testicular volume

Andrologia
Mohamed ArafaHaitham Elbardisi

Abstract

Seminal oxidative stress (OS) is a major cause of male factor infertility and can be measured as oxidation-reduction potential (ORP). Studies showed significant negative relationships of ORP with sperm count, motility or DNA integrity. Since these parameters are also positively or negatively associated with reproductive hormones follicle-stimulating hormone (FSH), luteinising hormone (LH), testosterone, testicular volume and the occurrence of varicocele, it is important to understand the mechanistic relationship between ORP and hormonal and/or testicular parameters. Therefore, we studied the relationship between ORP levels, standard hormone profiles and testicular volume in infertile men with and without varicocele. Results show a highly significant negative relationship of ORP with testicular volume and significantly positive correlations with FSH and LH. Yet, when adding varicocele as covariate, the relationship with FSH/LH became nonsignificant. Contrary, the presence of varicocele had only a contributing influence on the association of ORP with the testis volume. No association was found with estradiol. We propose that since OS causes degeneration of Sertoli cell with testicular shrinkage, such negative effect would result ...Continue Reading

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Citations

Jan 21, 2020·Human Fertility : Journal of the British Fertility Society·Takashi TanakaHiroshi Okada
May 14, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel
Aug 11, 2020·The World Journal of Men's Health·Ashok AgarwalRupin Shah
Oct 14, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ozge Senem Yucel CicekSerdar Filiz
Jul 27, 2021·Andrologia·Zohreh Talebi-YazdabadiMohammad Hossein Nasr-Esfahani
Sep 3, 2021·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Peter HumaidanSandro C Esteves

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