PMID: 5904979Jan 1, 1966

Correlation of peripheral white cell and bone marrow changes with folate levels in pregnancy and their clinical significance

Journal of Clinical Pathology
S VaradiA Elwis

Abstract

Two hundred and thirty-eight ;megaloblastic' pregnancies are reviewed. Bone-marrow aspiration was performed in every case. Serum folate estimations were strongly suggestive of folic acid deficiency in only 34% of cases. If, however, the red cell folate was determined as well, there was an almost complete agreement with the changes in the erythroblasts. It is suggested that hyper-segmentation of the neutrophils in association with a diminished red cell folate level is indicative of significant folic acid deficiency. This series possibly shows a slight but statistically insignificant increase of accidental haemorrhage. No effect on birth weight or incidence of stillbirth was demonstrable.

References

Dec 27, 1958·Lancet·C GILES, E M SHUTTLEWORTH
Jul 1, 1960·British Journal of Haematology·N GROSSOWICZB BERCOVICI
Oct 15, 1960·British Medical Journal·A MACKENZIE, J ABBOTT
Jul 1, 1961·Journal of Clinical Pathology·A H WATERS, D L Mollin
Aug 1, 1964·The Journal of Obstetrics and Gynaecology of the British Commonwealth·B M HIBBARD
Nov 28, 1964·British Medical Journal·M CHISHOLM, A A SHARP
May 1, 1965·Journal of Clinical Pathology·J M SCOTT, J W SOMMERVILLE

Citations

Jan 1, 1977·Archives of Disease in Childhood·G Gandy, W Jacobson
Sep 1, 1995·Baillière's Clinical Haematology·R Green
Oct 1, 1979·Journal of the American Geriatrics Society·S G Webster, J T Leeming
Jan 1, 1974·Multivariate Behavioral Research·L Macbeth
May 11, 2006·The American Journal of Clinical Nutrition·Tsunenobu Tamura, Mary Frances Picciano
Sep 1, 1973·CRC Critical Reviews in Clinical Laboratory Sciences·H E SauberlichJ H Skala
Sep 1, 1969·Scottish Medical Journal·R H Girdwood
Jan 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S C Tso, R L Wong

Related Concepts

Anemia, Macrocytic
Blood
Bone Marrow Examination
Folic Acid, Sodium Salt
Folic Acid Deficiency
Differential White Blood Cell Count Procedure
Pregnancy Complications, Hematologic

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