Correlation of plasma propranolol concentration with therapeutic response in patients with angina pectoris

Circulation
M PineC Chidsey

Abstract

The therapeutic response to propranolol was evaluated in patients with documented coronary artery disease at doses varying from 40 to 320 mg/day. Therapeutic response was quantified by evaluating exercise performance on a treadmill and then related to plasma propranolol concentration. Plasma propranolol was defined in terms of beta-adrenergic blockade by comparison with dose (concentration) response curves in normal subjects. Individual therapeutic benefit occurred at doses which averaged 144 +/- 21 mg/day and at concentrations which averaged 30 +/- 7 ng/ml. There was a wide variation between both dose and concentration among the patients at maximum therapeutic response, but when the plasma propranolol was related to pharmacologic activity, the maximum therapeutic response was observed between 64 to 98% of total blockade. Despite the increased exercise performance in these patients, the double product of heart rate and systolic blood pressure was always less, suggesting either an alteration of the relation between myocardial oxygen consumption and the double product during propranolol or a reduction on oxygen delivery to the myocardium as the result of beta-adrenergic blockade of the coronary vasculature.

References

Nov 1, 1971·European Journal of Pharmacology·M M WinburyB B Howe
Mar 1, 1972·Clinical Pharmacology and Therapeutics·C R Cleaveland, D G Shand
Oct 1, 1972·The Biochemical Journal·A G Renwick, R T Williams
Sep 26, 1973·Journal of Chromatography·E Di SalleP L Morselli
Oct 6, 1969·JAMA : the Journal of the American Medical Association·E A AmsterdamS Wolfson
Dec 1, 1967·Annals of Internal Medicine·R E GianellyD C Harrison
Nov 1, 1969·Archives of Internal Medicine·H J ZeftE S Orgain
Nov 1, 1969·Archives of Internal Medicine·T T Zsotér, D S Beanlands
Nov 1, 1965·British Heart Journal·J Hamer, E Sowton
Jan 1, 1970·Clinical Pharmacology and Therapeutics·D G ShandJ A Oates
Apr 1, 1970·Cardiovascular Research·B Pitt, P Craven
Aug 1, 1971·Journal of Applied Physiology·T A KotchenJ W Mason
Jan 1, 1968·The American Journal of Cardiology·J O ParkerS Di Giorgi
Nov 1, 1965·The Journal of Clinical Investigation·S EpsteinE Braunwald
May 1, 1966·Canadian Journal of Physiology and Pharmacology·G R Cumming, W Carr
Sep 1, 1966·The American Journal of Cardiology·E Sowton, J Hamer
Sep 1, 1966·The American Journal of Cardiology·S WolfsonR Gorlin
Dec 1, 1955·The American Journal of Physiology·A ALELLAL N KATZ

❮ Previous
Next ❯

Citations

Apr 1, 1979·Clinical Cardiology·C A BertolasiM I Lugones
Jan 1, 1980·Pharmacology & Therapeutics·B N Prichard, C W Owens
Jul 5, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Y YamadaT Iga
Jun 29, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·W C StewartJ A Stewart
Oct 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ashish MehtaWinston Shim
Jan 1, 1979·British Heart Journal·R T Krediet, A J Dunning
Sep 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·D JeffersonC D Marsden
Jun 20, 2001·Biological & Pharmaceutical Bulletin·Y TashiroK Itoh
Dec 1, 1981·Controlled Clinical Trials
Jul 1, 1983·Journal of Pharmaceutical Sciences·B M SilberS Riegelman
Oct 1, 1977·Journal of Pharmaceutical Sciences·R E Kates, C L Jones
Jun 1, 1982·Journal of Pharmaceutical Sciences·B SilberS Riegelman
Jun 1, 1978·American Heart Journal·H D Sostman, R A Langou
Jul 1, 1980·The American Journal of Cardiology·U Thadani, J O Parker
Mar 1, 1983·The American Journal of Cardiology·L G Sherman, C S Liang
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E BercoffD Lebrec
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Garcia-TsaoJ L Alberts
Jun 1, 1983·British Journal of Clinical Pharmacology·C T DolleryG Cuisinaud
Jun 1, 1989·British Journal of Clinical Pharmacology·P CalèsJ P Pascal
Apr 1, 1985·Journal of Clinical Pharmacology·L D DeLeveF H Leenen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.