Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics

Lancet
Osama SabriU Buell

Abstract

Studies of schizophrenia by single photon emission computed tomography (SPECT) and positron emission tomography (PET) have shown both regional cerebral hyperperfusion and hypoperfusion. The aim of this study was to examine the inter-relations between regional cerebral blood flow (rCBF), psychopathology, and effects of neuroleptic therapy. 24 never-treated patients with acute schizophrenia were examined with hexamethylpropyleneamine-oxime brain SPECT and assessed psychopathologically according to the positive and negative syndrome scale; they were studied again after neuroleptic treatment and psychopathological remission. rCBF values that deviated from those of 20 controls by more than 2 SD were regarded as abnormal. Both hyperperfused and hypoperfused patterns were found among schizophrenia patients during acute illness. The seven positive symptoms on the symptom scale showed different correlations with rCBF: formal thought disorders and grandiosity correlated positively (and strongly) with bifrontal and bitemporal rCBF; delusions, hallucinations, and distrust correlated negatively (and strongly) with cingulate, left thalamic, left frontal, and left temporal rCBF. Stereotyped ideas as a negative symptom correlated negatively (a...Continue Reading

References

Dec 1, 1992·Archives of General Psychiatry·A WolkinJ Rotrosen
Dec 1, 1992·Nuclear Medicine Communications·G M SyedB K Toone
Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P F LiddleR S Frackowiak
Jun 1, 1988·Archives of General Psychiatry·H SzechtmanJ M Cleghorn
Oct 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·N D VolkowR Cancro
Dec 1, 1987·Acta Psychiatrica Scandinavica·F A WieselS Stone-Elander
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1984·Annals of Neurology·J D BrodieN D Volkow
Feb 1, 1996·Acta Psychiatrica Scandinavica·J D MellersR M Murray

❮ Previous
Next ❯

Citations

Aug 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Marco PaganiAnn Gardner
Jan 30, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Osama SabriPeter Brust
Apr 19, 2005·European Archives of Psychiatry and Clinical Neuroscience·M SoykaK Tatsch
Jun 20, 2006·European Archives of Psychiatry and Clinical Neuroscience·Heli TuppurainenJari Tiihonen
Dec 5, 2008·European Archives of Psychiatry and Clinical Neuroscience·Astrid KnobelMartin Voss
Jul 11, 2006·Wiener medizinische Wochenschrift·Felipe OrtuñoRaphael M Bonelli
Mar 4, 2000·Journal of Psychiatric Research·F X VollenweiderK L Leenders
May 14, 1999·Trends in Pharmacological Sciences·M ZoliK Fuxe
Oct 20, 2001·Behavioural Brain Research·L Fernández-Novoa, R Cacabelos
Nov 13, 2001·Clinical Psychology Review·R P BentallP Kinderman
Dec 26, 2001·Brain Research Bulletin·F X Vollenweider, M A Geyer
May 30, 2001·Schizophrenia Research·M StephaneN N Boutros
Dec 1, 2001·Schizophrenia Research·U SchneiderH M Emrich
Mar 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Igor ElmanScott E Lukas
Apr 12, 2003·Epilepsia·Fritz LeutmezerChristoph Baumgartner
Mar 4, 2010·Cognitive Neuropsychiatry·Claude M J Braun, Sabrina Suffren
Mar 6, 2007·Psychopathology·Hanns Jurgen KunertPaul Hoff
Jul 17, 2012·Neuropsychobiology·Anne PankowAndreas Heinz
Jul 17, 2012·Neuropsychobiology·Helge HornWerner Strik
Nov 3, 2010·Psychiatry Research·Keith Richard LawsAnne-Marie Nillo
Feb 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Helge HornWerner Strik
Apr 1, 2010·PET Clinics·Andrew B Newberg, Abass Alavi
Jan 27, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nobuhisa KanaharaMasaomi Iyo
Mar 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dorit Ben-ShacharNanette Freedman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.