PMID: 6967203Jan 1, 1980Paper

Correlation of preoperative immunologic test results with recurrence in patients with head and neck cancer

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
R E RyanR E Ritts

Abstract

Numbers and percentages of T and B cells in peripheral blood; blastogenic responses to PHA, Con A, and PWM; and serum levels of albumin, total protein, and IgA were assessed in patients with stages I to III operable squamous cell carcinoma of the upper aerodigestive passageways in the head and neck. The patients were categorized into two groups: those who remained tumor free and those in whom cancer recurred. It was found that pretreatment PHA- and Con A-induced blastogenesis was often depressed in patients in whom clinically apparent recurrences developed regardless of stage or nodal involvement. This point is consistent with the idea that cellular immune function (blastogenesis) can identify, within the clinical staging system (TN), subpopulations of patients who are less likely to survive after conventional therapy.

References

Apr 1, 1977·Archives of Otolaryngology·J M MasonB R Jennings
Oct 11, 1975·American Journal of Surgery·Z L Olkowski, S A Wilkins
Jul 11, 1975·American Journal of Clinical Pathology·M L SebelR E Ritts
Oct 1, 1975·American Journal of Surgery·H J WaneboH Oettgen
Feb 24, 1972·The New England Journal of Medicine·W J CatalonaP B Chretien

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Citations

Nov 1, 1986·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M Mandell-BrownR L Wagner
Jul 1, 1981·Head & Neck Surgery·J G BatsakisD H Rice
Aug 1, 1984·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J T JohnsonP B Thearle

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