PMID: 8948342Oct 1, 1996Paper

Correlation of pretherapy prostate cancer characteristics with seminal vesicle invasion in radical prostatectomy specimens

International Journal of Radiation Oncology, Biology, Physics
T M PisanskyH Zincke

Abstract

This study was conducted to identify pretherapy factors associated with seminal vesicle invasion (SVI) in patients with localized carcinoma of the prostate (CaP), and to develop a model that would allow estimation of the likelihood for SVI at the time of initial diagnosis. Between January 1988 and December 1993, 2959 patients underwent radical retropubic prostatectomy, with or without pelvic lymph node dissection, as initial therapy for clinical Stage T1a-3bN0-XM0 CaP. Preoperative patient and tumor-related characteristics were evaluated for an association with SVI in univariate and multivariate logistic regression analyses. A model was developed and probability plots were constructed to display the estimated likelihood for SVI in the patients with a new diagnosis of localized CaP. Within clinical tumor stage, three groups (T1a-2a, T2b-c, and T3a-b) were observed to have a distinctly different rate of SVI. Gleason primary grades were combined (1-2, 3 and 4-5) because of a similar observation. Univariate analysis identified clinical tumor stage (p < 0.0001), Gleason primary grade (p < 0.0001), and serum prostate-specific antigen level (p < 0.0001) as factors associated with the likelihood for SVI. Multivariate analysis confirmed...Continue Reading

References

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Citations

Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurent SalomonJean-Leon Lagrange
Aug 6, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J C StroomB J Heijmen
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·L CellaR Miralbell
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Larry KestinAlvaro Martinez
Apr 3, 2008·Current Opinion in Urology·Shahrokh F ShariatMichael W Kattan
Dec 17, 2009·Future Oncology·Shahrokh F ShariatPeter T Scardino
Mar 31, 2011·Medicinski pregled·Goran MarusićIvan Levakov
Jul 13, 2005·Mayo Clinic Proceedings·Thomas M Pisansky
Feb 7, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Paul M A van HaarenUulke A van der Heide
Oct 1, 2008·Cancer·Shahrokh F ShariatMichael W Kattan
Jul 14, 2010·The Prostate·Umberto CapitanioVincenzo Scattoni
Jan 5, 2011·Journal of Medical Imaging and Radiation Oncology·A J HaydenUNKNOWN Australian & New Zealand Faculty of Radiation Oncology Genito-Urinary Group
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Thomas M Pisansky
Dec 31, 1998·Annals of Diagnostic Pathology·D G Bostwick, K A Iczkowski
May 9, 2001·The Journal of Urology·P L RossM W Kattan
Nov 27, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H J FeldmannT Wiegel
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shahrokh F ShariatKevin M Slawin

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