PMID: 6159065Oct 15, 1980Paper

Correlation of prognostic factors and blood lymphocyte subtypes in non-Hodgkin's lymphoma

Cancer
J L MurrayA F Lobuglio

Abstract

The total lymphocyte, T, B, and null cell content of peripheral blood from 32 healthy individuals and 30 patients with non-Hodgkin's lymphoma was determined. The patients had a significant reduction of B cells (complement receptor and membrane immunoglobulin positive cells) and a significant reduction in T cells. Correlation of patients' characteristics with lymphocyte abnormalities demonstrated several findings. Patients with advanced disease (III and IV) had significantly lower total lymphocyte and T cells than patients with localized disease (I and II) or normal controls. Patients with hypogammaglobulinemia had lower total lymphocyte and T cells than patients with normal gamma globulin status or normal controls. Patients with diffuse histology and B symptoms had lower total lymphocyte and T cells than normal controls. Discriminant analysis of lymphocyte populations categorized patients by disease extent and gamma globulin status with 70 and 68% accuracy, respectively.

References

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Citations

Jun 1, 1983·European Journal of Cancer & Clinical Oncology·C Simonsson-LindemalmA Ost
Oct 1, 1987·American Journal of Hematology·A Janowska-WieczorekL M Pilarski

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