Correlation of Radiation Dose Estimates by DIC with the METREPOL Hematological Classes of Disease Severity

Radiation Research
Matthias PortM Abend

Abstract

The degree of severity of hematologic acute radiation syndrome (HARS) may vary across the range of radiation doses, such that dose alone may be a less reliable predictor of clinical course. We sought to elucidate the relationship between absorbed dose and risk of clinically relevant HARS in humans. We used the database SEARCH (System for Evaluation and Archiving of Radiation Accidents based on Case Histories), which contains the histories of radiation accident victims. From 153 cases we extracted data on dose estimates using the dicentric assay to measure individual biological dosimetry. The data were analyzed according to the corresponding hematological response categories of clinical significance (H1-4). These categories are derived from the medical treatment protocols for radiation accident victims (METREPOL) and represent the clinical outcome of HARS based on severity categories ranging from 1-4. In addition, the category H0 represents a post-exposure hematological response that is within the normal range for nonexposed individuals. Age at exposure, gender and ethnicity were considered as potential confounders in unconditional cumulative logistic regression analysis. In most cases, victims were Caucasian (82.4%) and male (9...Continue Reading

References

Apr 1, 1997·Health Physics·R E GoansR C Ricks
Nov 30, 2000·Radiation and Environmental Biophysics·I FrieseckeT M Fliedner
Nov 23, 2001·The British Journal of Radiology·I FrieseckeUNKNOWN METREPOL team. Medical treatment protocols for radiation accident victims as a basis for a computerised guidance system
Apr 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kai Rothkamm, Markus Löbrich
Oct 12, 2005·Health Physics·Ronald E Goans, Jamie K Waselenko
Jul 19, 2013·Radiation Research·K RothkammM Abend
Jul 19, 2013·Radiation Research·C BeinkeM Abend
Dec 3, 2013·International Journal of Radiation Biology·Elizabeth A AinsburyAndrzej Wojcik

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Citations

Jul 23, 2019·Radiation Protection Dosimetry·Matthias PortMichael Abend
Aug 29, 2020·Oxidative Medicine and Cellular Longevity·Liren Qian, Jian Cen
Dec 24, 2018·Radiation Protection Dosimetry·Michael Abend, Matthias Port
May 22, 2020·The Science of the Total Environment·Bin WangSai-Jun Fan
Jul 14, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Andreas LamkowskiMatthias Port
Jul 20, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·William F BlakelyMichael Abend

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Methods Mentioned

BETA
chromosomal aberrations

Software Mentioned

SEARCH
METREPOL
SAS

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