PMID: 9178827May 16, 1997Paper

Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis

International Journal of Cancer. Journal International Du Cancer
C G WuR A Chamuleau

Abstract

Using a subtraction-enhanced display technique, we identified a rodent alpha-tocopherol transfer protein (alpha-TTP) cDNA which exhibited markedly lower messenger RNA (mRNA) amounts in rat hepatocellular carcinoma (HCC) than in healthy controls. Several lines of evidence have substantiated that abnormal alpha-TTP results in isolated vitamin E deficiency. In this study, we investigated the hepatic mRNA amounts of alpha-TTP during rat hepatic carcinogenesis and liver regeneration on Northern blot, localization of alpha-TTP mRNA in HCC of rats and humans by in situ hybridization, and we analyzed the correlation between alpha-TTP mRNA and alpha-tocopherol. alpha-TTP mRNA concentrations of the rats were decreased at the early stage of hepatic carcinogenesis, and remained 3-5-fold reduced as the tumor progressed. In parallel, serum alpha-tocopherol concentrations were significantly decreased to 40% of those in the controls at the early stages of rat hepatic carcinogenesis (p < 0.01). The 2 data sets were strongly correlated (r = 0.834, p < 0.001). In situ hybridization revealed that a decrease of alpha-TTP mRNA was preferentially localized in the tumor nodules of rats and humans with HCC. Our data suggest that repressed transcription...Continue Reading

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Citations

Jan 1, 1999·Indian Journal of Clinical Biochemistry : IJCB·H LalS K Aggarwal
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R RicciarelliA Azzi
May 30, 2002·Biological Chemistry·Roberta RicciarelliAngelo Azzi
Mar 9, 2005·Annals of the New York Academy of Sciences·Angelo AzziJean-Marc Zingg
Aug 21, 2004·Biological Chemistry·Angelo AzziJean-Marc Zingg
May 1, 2005·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Angelo Azzi, Jean-Marc Zingg
Oct 31, 2003·Molecular Aspects of Medicine·A AzziJ-M Zingg

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