Correlation of Rheumatoid Arthritis activity indexes (Disease Activity Score 28 measured with ESR and CRP, Simplified Disease Activity Index and Clinical Disease Activity Index) and agreement of disease activity states with various cut-off points in a Northeastern Brazilian population

Revista brasileira de reumatologia
Marta Maria das Chagas MedeirosÍdila Mont'Alverne Xavier de Oliveira

Abstract

The Disease Activity Score 28 (DAS28) and its versions have been used to measure rheumatoid arthritis (RA) activity, but there is no consensus about which one is the best. Determine the correlation among indexes (DAS28 ESR, DAS28 CRP, SDAI and CDAI) and evaluate agreement of activity strata using different cutoff points. Rheumatoid arthritis patients were cross-sectionally evaluated with data collection to calculate the DAS28 (ESR and CRP), SDAI and CDAI, using different cut-offs for defining remission, mild, moderate and high activity. Pearson correlations were calculated for continuous measures and agreement (kappa test) for the strata (remission, mild, moderate and high activity). Of 111 patients included, 108 were women, age 55.6 years, 11-year disease duration. DAS28 (ESR) was significantly higher than DAS28 (CRP) (4.0 vs. 3.5; p<0.001) and the values remained higher after stratification by age, gender, disease duration, rheumatoid factor and HAQ. Correlations among indexes ranged from 0.84 to 0.99, with better correlation between SDAI and CDAI. Agreements among activity strata ranged from 46.8% to 95.8%. DAS28 (CRP) with cut-off point for the remission of 2.3 underestimated disease activity by 45.8% compared with DAS28 (E...Continue Reading

References

Sep 6, 2005·Arthritis and Rheumatism·Daniel AletahaJosef S Smolen
Aug 7, 2007·Best Practice & Research. Clinical Rheumatology·Daniel Aletaha, Josef S Smolen
Jul 9, 2009·Scandinavian Journal of Rheumatology·B RintelenB F Leeb
Aug 22, 2009·Modern Rheumatology·Nilton Salles Rosa NetoYehuda Shoenfeld

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Citations

Mar 31, 2018·Clinical Rheumatology·Gabriela Piovezani RamosRenato Nisihara
Nov 21, 2017·International Journal of Rheumatic Diseases·Ricardo Restrepo-CorreaCarlos J Velásquez-Franco
Aug 2, 2019·Journal of Immunoassay & Immunochemistry·Camila Medeiros CostaAndrei Pereira Pernambuco
Oct 11, 2016·Journal of Bone and Mineral Metabolism·Hani M KhojahAl-Badr Hamza
Aug 5, 2020·The American Journal of Tropical Medicine and Hygiene·Maira Sant Anna GenaroRenata Dezengrini Slhessarenko

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